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  • Antitumoral activities  (1)
  • Musculoskeletal neoplasms  (1)
  • 1
    Electronic Resource
    Electronic Resource
    7-Hydroxycoumarin inhibits oncogene-induced transformation of murine fibroblasts (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. S23 
    Details
    ISSN: 1432-1335
    Keywords: 7-Hydroxycoumarin ; Antitumoral activities ; Oncogene ; Transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 7-Hydroxycoumarin (7-HC) is a naturally occuring substance with a variety of biological activities, e.g. antitumoral and immunomodulatory action. the potential mechanisms of 7-HC action on tumor cells have been investigated in a model of mouse fibroblasts transformed by distinet retroviral vectors carrying the oncogenesmyc andras. Treatment of the different oncogenic transformants with 7-HC in non-cytotoxic concentrations causes a strong inhibition of their proliferative capacity as measured by growth curves. Furthermore, incubation of theras andmyc transformants with 7-HC abrogated soft agar colony formation when compared to untreated cultures. These changes in cell growth characteristics of the various oncogene-transformed mouse fibroblasts were transient, since removal of 7-HC from the cultures caused a reappearance of the transformed properties of these cells within 6 days. The 7-HC-mediated inhibition of the proliferative capacity of the transformants was preceded by a selective down-regulation of oncogene expression. These data suggest that 7-HC causes a reversible inhibition ofras- andmyc-induced neoplastic properties in transformed fibroblasts by selective down-regulation of retroviral RNA levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01377119
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Magnetic resonance imaging of bone and soft tissue tumors: Early experience in 31 patients compared with computed tomography (1985)
    Springer
    Skeletal radiology 13 (1985), S. 134-146 
    Details
    ISSN: 1432-2161
    Keywords: Magnetic resonance imaging ; Musculoskeletal neoplasms ; Computed tomography of musculoskeletal neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 31 patients with 21 soft tissue and 10 bone tumors, magnetic resonance imaging (MRI) and computed tomography (CT) were equally effective in delineating the margins of most soft tissue tumors, and the margins of bone tumors from fat and adjacent normal bone. However, MRI was superior to CT in delineating bone tumors from adjacent muscle, and in showing the relationships to bone of the deep margins of some soft tissue tumors. This was true because the quality of CT images around thick cortical bone often was severely degraded by streak artifact, which does not occur in MRI. Excellent anatomic detail was achieved on MRI by spin echo pulse sequences with short repetition times. Bone tumors were delineated best by spin echo 1000/30 images, and soft tissue tumors by spin echo 1000/30 or inversion recovery images.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00352084
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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