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Passive transfer of demyelination by experimental allergic neuritis serum (1980)

Hahn, A. F. ; Gilbert, J. J. ; Feasby, T. E.

Springer

Acta neuropathologica 49 (1980), S. 169-176

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ISSN: 1432-0533

Keywords: Experimental allergic neuritis ; Demvelination ; Humoral immunity ; Myelin ; Schwann cell

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Serum from rabbits with experimental allergic neuritis (FAN) when injected into rat sciatic nerves produced rapidly evolving demyelination followed by remyelination. Myelinating and non-myelinating Schwann cells as well as myelin itself were damaged by 15 min after injection. Myelin degradation was well advanced prior to involvement by macrophages at 12 h. The demyelinating factor was myelin-specific and complement-dependent. The evidence suggests that the FAN antigen may reside in Schwann cell membranes as well as in myelin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00707103

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