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Digitale Medien

Selective involvement of monocytes by acquired myeloperoxidase deficiency in a case of chronic myelomonocytic leukemia (1993)

Pasquale, A. ; Ginaldi, L. ; Leonardo, G. ; [weitere]

Springer

Annals of hematology 66 (1993), S. 261-264

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Details

ISSN: 1432-0584

Schlagwort(e): Myeloperoxidase deficiency ; Chronicmyelomonocytic leukemia

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The authors describe a case of chronic myelomonocytic leukemia in which a myeloperoxidase (MPO) deficiency of circulating monocytes was first detected by automated differential cell counting, and subsequently confirmed by cytochemical and immunocytochemical investigations. MPO activity in neutrophil granulocytes from the same case was found to be normal. MPO deficiency in monocytes appeared to be associated with impaired phagocytic capacity and, based on the results of immunophenotypic and ultrastructural studies, was most likely attributable to a partial maturation arrest of monocytes. The present case suggests that MPO deficiency in myelodysplastic syndromes may have its origin in a number of different pathogenetic mechanisms.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01738477

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