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  • 1
    Electronic Resource
    Electronic Resource
    Lupus anticoagulant associated syndrome in benign and malignant systemic disease (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 818-822 
    Details
    ISSN: 1432-1440
    Keywords: Lupus anticoagulant ; Systemic lupus erythematosus ; Paraproteinemia ; Lymphoproliferative diseases ; Multiple myeloma ; Myeloproliferative diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A strong correlation exists between the presence of an in vitro plasma coagulation inhibitor, named “lupus anticoagulant”, and a clinical syndrome of recurrent arterial and venous thromboses, neurological abnormalities, repeated obstetrical complications, thrombocytopenia, a biologic false-positive serological test for syphilis, and a variety of rarer manifestations. This syndrome has predominantly been observed in patients with autoimmune diseases, but it may be of similar importance in association with monoclonal gammopathies. As an introduction to a detailed analysis of ten observations which will also be published in this journal, this article reviews the clinical findings, the proposed pathogenetic mechanisms and the approaches to management of the lupus anticoagulant associated syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727476
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Frequent association of idiopathic myelofibrosis with plasma cell dyscrasias (1988)
    Springer
    Annals of hematology 56 (1988), S. 97-102 
    Details
    ISSN: 1432-0584
    Keywords: Myelofibrosis ; Myeloproliferative diseases ; Paraproteinemia ; Multiple Myeloma ; Lymphoproliferative diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a retrospective analysis of 199 cases of myeloproliferative diseases a concomitant plasma cell dyscrasia was found in three out of 46 patients with idiopathic myelofibrosis. Chronic myeloid leukemia, polycythemia vera or unclassifiable myeloproliferative disorders were in no case associated with monoclonal gammopathy. One patient with idiopathic myelofibrosis had primarily coexistent IgG-λ paraproteinemia and increasing osteolytic lesions; histologic evidence of multiple myeloma, however, was insufficient. In the second patient the interval between diagnosis of idiopathic myelofibrosis and IgG-κ paraproteinemia was 11 years. After a stable period of 9 years' duration the paraprotein level rapidly increased, associated with depression of normal background immunoglobulins and progressive bone marrow failure. The exact nature of this patient's malignant plasma cell dyscrasia remained uncertain. In the third case benign monoclonal gammopathy of the IgM-λ type was diagnosed 13 years after idiopathic myelofibrosis. A review of the literature confirms a remarkably high incidence of monoclonal gammopathies in idiopathic myelofibrosis. Benign monoclonal gammopathy seems to occur in at least 8% of the patients while only a few cases of concomitant multiple myeloma have been reported. It may be speculated that plasma cell dyscrasias in idiopathic myelofibrosis reflect involvement of the lymphoid lineage in the neoplastic stem cell disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320010
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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