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  • 1
    Electronic Resource
    Electronic Resource
    Myofibroblasts in soft tissue sarcomas (1980)
    Springer
    Virchows Archiv 389 (1980), S. 1-11 
    Details
    ISSN: 1432-2307
    Keywords: Soft tissue sarcoma ; Myofibroblasts ; Ultrastructure ; Host response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A series of 129 soft tissue sarcomas was examined ultrastructurally to determine in which neoplasms and to what extent myofibroblasts could be demonstrated. Twenty cases of fibromatosis and fasciitis served as controls. Myofibroblasts were identified in all 30 cases of malignant fibrous histiocytoma and all 4 cases of well-differentiated sclerosing liposarcoma. Though most numerous in areas of desmoplasia, in no instance did myofibroblasts constitute the dominant cellular constituent of either neoplasm. Myofibroblasts were identified with lesser frequency and in smaller numbers in fibrosarcoma, synovial sarcoma, malignant hemangiopericytoma and neuroblastoma. None were observed in a wide assortment of diverse sarcomas in which desmoplasia was not a feature. In comparison each lesion judged by light microscopy to represent either fibromatosis or fasciitis was composed principally of myofibroblasts. The demonstration of abundant myofibroblasts within a soft tissue lesion which has been subjected to wide sampling strongly suggests a benign proliferative process as opposed to a malignant neoplasm. It is hypothesized that myofibroblasts observed within collagenized regions of soft tissue sarcomas may constitute an expression of host response to neoplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428664
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On the pathogenesis of sclerosis and nodularity in nodular sclerosing Hodgkin's Disease (1980)
    Springer
    Virchows Archiv 385 (1980), S. 283-291 
    Details
    ISSN: 1432-2307
    Keywords: Hodgkin's disease ; Myofibroblasts ; Ultrastructure ; Nodular sclerosis ; Host response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ten cases of nodular sclerosing Hodgkin's disease involving lymph nodes were studied by electron microscopy to determine the ultrastructural composition of the nodule-stromal interphase and the collagenized regions. In addition to a few lymphocytes, rare eosinophils and neutrophils, abundant filamentous and granular electron dense material, collagen fibers and myofibroblasts were observed in all instances. Since myofibroblasts possess contractile and synthetic properties, it is likely they contribute to the retraction and sclerosis which together represent one of the morphologic hallmarks of the disease. The dense fibrosis and contractile state of such tissue may constitute a beneficial host response to contain and limit local and vascular invasion by the neoplastic cellular population, thus contributing to the relative benignity of this form of Hodgkin's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432538
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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