ISSN:
1572-8870
Keywords:
Polymer–ferrocene conjugates
;
N-succinimidyl 4-ferrocenylbutanoate
;
polyamide carriers
;
intrachain anchoring sites
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract It is the objective of this project to synthesize polymer–ferrocene conjugates from macromolecular carriers in which the “anchoring” sites are main-chain constituents, thus contrasting with previously described conjugates featuring side-chain terminals as anchoring sites. To this end, earlier-developed polyamide carriers containing secondary amino groups in the main chain are treated with the active N-succinimidyl ester of 4-ferrocenylbutanoic acid in DMF solution. Molar feed ratios are chosen so as to favor the incorporation of a single ferrocenyl group per recurring unit. The water-soluble, microanalytically and spectroscopically characterized conjugates are of interest as antiproliferative agents in cancer research.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1021436126927
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