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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 152 (1993), S. 896-899 
    ISSN: 1432-1076
    Keywords: Neutrophil ; Inflammation ; Immunodeficiency ; Granuloma ; Chronic granulomatous disease ; Infection ; Antibiotics ; Interferon ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic granulomatous disease (CGD) is a primary immunodeficiency disease which results from absence of the NADPH oxidase in the professional phagocytic cells [13] neutrophils, monocytes, macrophages and eosinophils. Deficiency of this oxidase renders the patient liable to infection by bacteria and fungi, and, as the name of the disease suggests, to chronic granulomatous inflammation. These patients present with a great variety of infections and other complications of their disease, which often tax the clinical and therapeutic skill of the doctors responsible for their care. Collectively we look after, or advise on the management of, over 100 of these subjects, and have developed experience in the diagnosis and management of the infections and other clinical problems they present. We thought that it might be timely to provide guidelines for their management based upon this experience. The numbers of patients are still relatively small, and the clinical presentations very varied, so it is immpossible to provide clear statistical proof of the veracity of this advice. It does, however, reflect the working practise of the physicians caring for many of these patients in Europe.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of engineering mathematics 34 (1998), S. 21-44 
    ISSN: 1573-2703
    Keywords: Navier-Stokes ; finite volume discretization ; staggered grids ; boundary-fitted coordinates.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Technology
    Notes: Abstract The classical staggered scheme for the incompressible Navier-Stokes equations is generalized from Cartesian grids to general boundary-fitted structured grids. The resulting discretization is coordinate-invariant. The unknowns are the pressure and the contravariant volume flux components. The grid can be strongly nonuniform and nonorthogonal. The smoothness properties of the coordinate mapping are carefully taken into account. As a result, the accuracy on rough grids is found to be at least as good as for typical finite element and nonstaggered finite volume schemes. Extension to compressible flows results in a scheme with Mach-uniform accuracy and efficiency for Mach numbers ranging from M = 0 to M 〉 1. Accurate discretization of two-equation turbulence models is also possible.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 6 (1986), S. 427-443 
    ISSN: 0271-2091
    Keywords: Navier-Stokes ; Equations ; Time Integration ; Penalty Function Approach ; Oscillating Flow ; Vortex Shedding ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In this paper a penalty finite element solution method for the unsteady Navier-Stokes equations for two-dimensional incompressible flow is described. The performances of the Euler implicit (EI) and the Crank-Nicolson (CN) time integration methods are analysed. Special attention is payed to the undamped pressure oscillations which can occur when the Crank-Nicolson integration rule is used in combination with the penalty function method. Stability and convergence properties are illustrated by means of the computation of fully developed oscillating flow between two flat plates. Furthermore, the von Karman vortex street past a circular cylinder is computed to demonstrate the behaviour of the time integration schemes for a more complicated flow. It is concluded that the EI method has its advantages over the CN method with respect to the damping of numerical oscillations. However, for flows with an important convective contribution, where physically originated oscillations may be present, the CN method is preferable.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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