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Digitale Medien

Negative cooperativity may explain flat concentration-response curves of ATP-sensitive potassium channels (1993)

Hehl, S. ; Neumcke, B.

Springer

European biophysics journal 22 (1993), S. 1-4

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Details

ISSN: 1432-1017

Schlagwort(e): Potassium channel ; Channel blockage ; Hill coefficient ; Negative cooperativity

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Physik

Notizen: Abstract Blockage of ATP-sensitive K+ channels by various drugs has been reported to exhibit a weak concentration dependence with Hill coefficients below unity. This phenomenon is interpreted by a negative cooperativity between K+ channels whereby drug binding to one channel lowers the drug affinities of neighbouring channels. Results are presented for a dimeric and a tetrameric channel model and compared with published experimental data.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00205806

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