ISSN:
1432-0533
Keywords:
Key words Perineuritis
;
Neuropathy
;
Nerve biopsy
;
Apoptosis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A 71-year-old man presented a 6-month history of progressive paresthesia of all four limbs. Sural nerve biopsy specimens showed dense mononuclear infiltrates in the perineurium and subperineurium, indicating sensory perineuritis. One section revealed disruption of the perineurial barrier. Perforin and granzyme B were present in the infiltrates, and apoptosis of perineurial cells was indicated by a terminal deoxynucleotidyl-transferase-mediated dUTP-digoxigenin nick end-labeling (TUNEL) method. These findings suggest T cell-mediated apoptosis of the perineurium and nerve injury caused by perineurial damage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00007444
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