ISSN:
1432-0533
Keywords:
Measles virus
;
Subacute sclerosing panencephalitis
;
Multiple sclerosis
;
Neuroadapted
;
Chronic neurological disorders
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The neurotropic effects, virologic behaviors and morphologic appearances of 4 strains of subacute sclerosing panencephalitis (SSPE) virus have been examined in organotypic cultures of hamster cerebellar tissue and have been compared with the Edmonston strain of measles virus in the same system. While measles virus caused extensive damage to nervous tissue, the SSPE strains, in general, exerted a less deleterious effect. All of the SSPE viruses replicated in this tissue. The SSPE strains showed morphologic variation ranging from normal measles-type virions to apparently nucleocapsid deficient forms. It is speculated that some of these differences between measles and SSPE virus may account for the differences in the in vivo conditions with which they are associated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00684668
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