ISSN:
1432-0878
Keywords:
Neuromuscular disease
;
Muscle culture
;
Tissue dissociation
;
Immunofluorescence
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Myogenic cells from mice homozygous for the lethal mutation “motor endplate disease” (med/med) were grown in culture. Like muscle cells taken from wild type (+/?) litter mates they fused to form myotubes which contracted, developed cross striations, and exposed acetylcholine receptors (AChR) on their surface. However, a decrease of 30% in the number of mononucleated cells per unit fresh weight of muscle was observed as early as 2–3 days postnatal, i.e., at least one week prior to the onset of physiological symptoms. Hence, in addition to influencing the functional maintenance of motor endplates, the med gene seems to control early events in muscle development.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00237809
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