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  • 1
    Electronic Resource
    Electronic Resource
    The volume of Purkinje cells decreases in the cerebellum of acrylamide – intoxicated rats, but no cells are lost (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 307-312 
    Details
    ISSN: 1432-0533
    Keywords: Key words Acrylamide ; Cerebellum ; Neuronal volume ; Neuronal number ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of acrylamide intoxication on the numbers of granule and Purkinje cells and the volume of Purkinje cell perikarya have been evaluated with stereological methods. The analysis was carried out in the cerebella of rats that had received a dose of 33.3 mg/kg acrylamide, twice a week, for 7.5 weeks. The total numbers of cerebellar granule and Purkinje cells were estimated using the optical fractionator and the mean volume of the Purkinje cell perikarya was estimated with the vertical rotator technique. The volumes of the molecular layer, the granular cell layer and the white matter were estimated using the Cavalieri principle. The mean weight of the cerebellum of the intoxicated rats was 7   % lower than that of the controls rats (2P = 0.001). The numbers of the Purkinje cells and granule cells were the same in both groups, but the mean volume of the perikarya of the Purkinje cells in the intoxicated rats was 10.5   % less than that of the control group (2P = 0.004). The volume of the granular cell layer was reduced by 15   % (2P = 0.006) but there were no differences in the volumes of the molecular layer and the white matter in the intoxicated and control animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310374
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  • 2
    Electronic Resource
    Electronic Resource
    Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers (1983)
    Springer
    Psychopharmacology 81 (1983), S. 199-207 
    Details
    ISSN: 1432-2072
    Keywords: Dopamine agonists ; Autoreceptors ; 3-PPP ; Neuroleptics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacological profile of the enantiomers of the proposed selective dopamine (DA) autoreceptor agonist 3-PPP [3-(3-hydroxyphenyl)-N-n-propylpiperidine] has been studied. In vitro both enantiomers showed weak DA agonistic activity, and (-)-3-PPP some DA antagonistic effect on DA-stimulated adenylate cyclase activity. Both enantiomers in low doses had a similar profile in vivo: Inhibition of locomotor activity of mice and rats, induction of contralateral circling behaviour in 6-hydroxy-DA-lesioned rats and an emetic effect in dogs. At higher doses, differential effects of the enantiomers were found: (+)-3-PPP induced hyperactivity, weak stereotyped behaviour and ipsilateral circling in hemitransected rats. (-)-3-PPP had depressant effects in high doses, inhibited d-amphetamine-induced hyperactivity and d-amphetamine-, methylphenidate- and apomorphine-induced stereotyped licking/biting in rats and antagonized apomorphine-induced emesis in dogs. However, (+)-3-PPP also showed a weak antagonistic activity against d-amphetamine-induced hyperactivity and d-amphetamine-and apomorphine-induced stereotypy in rats and inhibited apomorphine-induced emesis in dogs. It is suggested that both enantiomers have significant effects on postsynaptic DA receptors in high doses: (-)-3-PPP with weak antagonistic activity in some test models and (+)-3-PPP with agonistic and antagonistic effect. Since these effects of (+)-3-PPP were of low intensity at high doses, (+)-3-PPP may be a partial DA agonist at postsynaptic receptors in high doses. Interaction experiments with neuroleptics indicated that only (-)-3-PPP significantly increased the antistereotypic effect of neuroleptics in rats. Therefore, the proposed DA autoreceptor stimulation is possibly unrelated to the neuroleptic potentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427262
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  • 3
    Electronic Resource
    Electronic Resource
    Structural preservation of cerebellar granule cells following neurointoxication with methyl mercury: a stereological study of the rat cerebellum (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 251-256 
    Details
    ISSN: 1432-0533
    Keywords: Key words Cerebellum ; Neuronal volume ; Methyl ; mercury ; Neuronal number ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Methyl mercury intoxication causes ataxia. Structural changes of cerebellar and peripheral nerve tissues have been described. However, it is still unclear whether the ataxia is of cerebellar or peripheral origin. To clarify this question further, the effects of methyl mercury intoxication on the numbers of granule and Purkinje cells and the volume of Purkinje cell perikarya have been evaluated with stereological methods. Rats were intoxicated with methyl mercury, at a dose of 2 mg/kg per day for 19 successive days, and the analysis was carried out 2.5 or 4.5 weeks later. The total numbers of cerebellar granule cells and Purkinje cells were estimated using an optical fractionator and the mean volume of the Purkinje cells was estimated by the vertical rotator technique. The volumes of the granular cell layer, the molecular layer and the white matter were estimated using the Cavalieri principle. The intoxicated animals developed hindlimb incoordination when held by the tail. Although pronounced axonal degeneration occurred in the peripheral nervous system, no changes were found in cerebellar cell numbers or cell sizes in either of the test groups. The absence of detectable light microscopic changes in the cerebellum indicates that the peripheral nervous system is affected prior to the cerebellum in rats intoxicated with organic mercury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296508
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    Paper (German National Licenses)
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