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  • 1
    Electronic Resource
    Electronic Resource
    Improved assay of neurotoxic esterase for screening organophosphates for delayed neurotoxicity potential (1977)
    Springer
    Archives of toxicology 37 (1977), S. 113-115 
    Details
    ISSN: 1432-0738
    Keywords: Determination ; Neurotoxic esterase ; Neurotoxicity ; Organophosphate compounds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch Bestimmung der neurotoxischen Esterase (NTE) ist es möglich, im Gehirn von mit phosphororganischen Pflanzenschutzmitteln, Weichmachern und anderen Stoffen behandelten Hühnern die potentielle Neurotoxizität dieser Stoffe zu erfassen. Die ursprüngliche Methode [Johnson, M. K. Biochem. J. 114, 711–717 (1969)] wurde vereinfacht, so daß Zentrifugieren und Transferschritte nicht mehr erforderlich sind. Die Selektivität und Empfindlichkeit der Methode wurde verbessert. Die Herstellung stabiler Reagentienstammlösungen wird beschrieben.
    Notes: Abstract The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. to be assessed. The original assay [Johnson, M. K. Biochem. J. 114, 711–717 (1969)] has been simplified to eliminate centrifugation and transfer steps and both the selectivity and the sensitivity have been increased. The procedures necessary to obtain stable reagent stocks are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293860
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Repeated small doses of a neurotoxic organophosphate (1980)
    Springer
    Archives of toxicology 45 (1980), S. 263-271 
    Details
    ISSN: 1432-0738
    Keywords: Organophosphate neuropathy ; Organophosphate ; Chronic dosing ; Neurotoxic esterase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of small repeated oral doses of mono-2-cresyl diphenyl phosphate (MOCP, 2.5 mg/kg/day) on hen brain and spinal cord neurotoxic esterase (NTE) were measured. The enzyme levels were depressed to about 40% and 55% of normal respectively and maintained at that level for 8 weeks. No clinical and only doubtful histological signs of neuropathy were detected. Neuropathy could be precipitated by depressing the level to 〈 20% either with a single high dose (50 mg/kg), or by an increase of the repeated dose level to 5 mg/kg/day. There was no correlation between inhibition of NTE in the nervous tissue and the “NTE-like” activity in lymphocytes. “NTE-like” activity in spleen was consistently inhibited but to a lesser extent than that in the brain or spinal cord. Brain AChE and BuChE were not affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293807
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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