ISSN:
1434-4726
Keywords:
Apoptosis
;
Labyrinthine vestibule
;
Aminoglycoside toxicity
;
Zinc toxicity
;
Nick-end labeling
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We reported that apoptosis occurred in the guinea pig vestibular hair cells after chronic aminoglycoside treatments. In the present study, we used in situ nick-end labeling to determine whether apoptosis was also induced by the acute effects of aminoglycosides in guinea pig ampullar cristae. In addition, we evaluated the effect of zinc supplements upon these ototoxic treatments. After a local application of streptomycin directly to the round window, we found labeled bodies in the vestibular hair cells. The zinc supplement increased the number of labeled bodies resulting in severe hair cell loss. These findings indicate that the acute effects of aminoglycosides also induce apoptosis of the vestibular hair cells, and that zinc enhances aminoglycoside ototoxicity. Consequently, we propose that an interaction with ion channels may play a key mechanism in the processes of apoptosis affecting the vestibular hair cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02471281
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