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  • 1
    Digitale Medien
    Digitale Medien
    Metabolic effects of nicotine on human adipose tissue in organ culture (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 94-99 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Human adipose tissue ; Nicotine ; Lipoprotein lipase ; Glucose metabolism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Fragments of human adipose tissue were maintained in culture for 1 week in a medium containing 1 mU/ml insulin and 100 ng/ml dexamethasone. Under these conditions lipoprotein lipase activity was present in human adipose tissue fragments which converted [14C]glucose to 14C02 and [14C]triglyceride. Both metabolic parameters studied were affected by human tumor necrosis factor and brefeldin A. When fragments of human adipose tissue after 1 week in culture were incubated with nicotine tartrate for 20 h, a slight but significant increase in lipoprotein lipase activity was observed, and an increased conversion of [14C]glucose to 14CO2 and [14C] triglyceride occurred. Nicotin was taken up by human adipose tissue, but no conversion to cotinine was observed. Our data demonstrate a direct effect of nicotine on human adipose tissue metabolism. Furthermore, it is suggested that weight loss in smokers is a multifactorial phenomenon, and one of the important factors to be considered is the direct effect of nicotine within the tissue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00184583
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Glycogen storage disease, Fanconi nephropathy, abnormal galactose metabolism and mitochondrial myopathy (1989)
    Springer
    European journal of pediatrics 149 (1989), S. 48-51 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Glycogen storage disease ; Fanconi nephropathy ; Galactose ; Mitochondrial myopathy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We present a 4-year-old male suffering from profound muscular weakness, enzymatically undefined glycogen storage disease. Fanconi nephropathy and impaired galactose utilization. Distorted mitochondria, intramitochondrial fat droplets and partial deficiencies of pyruvate dehydrogenase complex, succinate: cytochrome c oxidoreductase, and cytochrome c oxidase have been found in muscle tissue. The causal relationship between mitochondrial myopathy, glycogen storage disease, Fanconi nephropathy and impaired utilization of galactose is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02024334
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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