ISSN:
1432-2013
Keywords:
Non-Respiratory Acidosis
;
Oxygen Transport
;
Oxygen Dissociation Curve
;
2,3-DPG
;
Hemorrhagic Shock
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary This study was designed to evaluate, in vivo, the effect of a severe non-respiratory acidosis on hemoglobin oxygen transport. Oxygen affinity of hemoglobin, Bohr effect, Hill's number and red cell 2,3-DPG were evaluated during experimental hemorrhagic shock in dogs. Three periods were considered: control, hypotension (mean arterial pressure 60 mm Hgfor 2 hr 30 min) and blood replacement. There was no significant change in erythrocyte 2,3-DPG following hemorrhagic hypotension but ATP increased significantly. n, the Hill number (2.6), was not changed by in vivo acidosis (pH 7.1). Respiratory Bohr coefficient (B CO2)corresponding to pHe variations was drastically reduced (controlB CO2=0.55, acidosisB CO2=0.31, blood replacementB CO2=0.35). P50(7.4) was not modified significantly by hemorrhagic acidosis. It is unlikely that variations of blood affinity for oxygen play a major role in oxygen delivery during early experimental hemorrhagic shock.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00581284
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