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  • Key words Heart-neoplasms — hemangioma — heart surgery — angina pectoris  (1)
  • Non-radioactive in situ hybridization  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Expression pattern of type II collagen mRNA during early vertebral development in the human embryo (1996)
    Springer
    Anatomy and embryology 193 (1996), S. 43-51 
    Details
    ISSN: 1432-0568
    Keywords: Type II collagen ; Human embryo ; Non-radioactive in situ hybridization ; Vertebral column ; Cartilage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of extracellular matrix molecules in ontogenetic differentiation processes is a matter of increasing interest. In cartilage development, type II collagen is suspected of promoting chondrogenic differentiation, since its expression has been demonstrated in a range of precartilaginous tissues of vertebrate species. Up to now, no studies supplying a coherent description of type II collagen expression in the skeletogenesis of human embryos including early embryonic stages have been published. In this work, we examine the temporal and spatial distribution of type II collagen mRNA during vertebral column development in human embryos from 4 to 12 weeks of gestation using non-radioactive in situ hybridization. The onset of gene expression was demonstrable in the 5th week in precartilaginous mesenchymal cells and in notochordal cells. Additionally, we found a weaker hybridization signal in the mesenchymal precursors of the intervertbral discs. In the anlagen of the axial skeleton, type II collagen expression decreased during osteogenic reconstruction in the 11th/12th week, whereas expression continued in the notochordal remnants of the future nuclei pulposi. The results suggest a relatively late occurrence of type II collagen in human vertebral development compared with other vertebrate species. The distribution of gene expression is concordant with a possible role of this molecule in promoting differentiation of mesenchymal cells into chondrocytes. The mechanism of this influence remains to be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186832
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Rezidivierende Angina pectoris bei Belastung verursacht durch ein Hämangiom des Herzens (1997)
    Springer
    Zeitschrift für Kardiologie 86 (1997), S. 545-548 
    Details
    ISSN: 1435-1285
    Keywords: Key words Heart-neoplasms — hemangioma — heart surgery — angina pectoris ; Schlüsselwörter Herztumoren — Hämangiome — Herzchirurgie — Angina pectoris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We present the case of a 73-year-old gentleman with a 3-week history of recurrent exertional angina confirmed by exercise stress testing. The symptoms were caused by hemangioma situated between the pulmonary artery and the left auricle. The diagnosis was confirmed by ventriculography, coronary angiography, and CT-scanning. The tumor was completely removed through a midline sternotomy without extracorporeal circulation. Histology revealed the diagnosis of a cavernous hemangioma with endothelial lined vascular channels of varying size. The patient made an uneventful recovery and remained asymptomatic during follow up. Cardiac hemangioma are rare tumors of the heart that may cause angina by interfering with the coronary blood flow. Surgery is curative for most patients.
    Notes: Zusammenfassung Ein Fall eines 73jährigen Patienten mit rezidivierender Angina pectoris bei Belastung, verursacht durch eine Hämangiom zwischen der Arteria pulmonalis und dem linken Herzohr, wird vorgestellt. Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert. Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt. Der postoperative Verlauf war unauffällig, und der Patient war beschwerdefrei. Hämangiome des Herzens sind seltene Tumoren, die durch eine Operation kurativ behandelt werden können.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003920050093
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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