ISSN:
1432-1912
Keywords:
Neuropeptide Y
;
Y2-receptor
;
Noradrenaline
;
Locus coeruleus
;
Receptor interaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Intracellular recordings were carried out in a pontine slice preparation of the rat brain containing the locus coeruleus (LC). Pressure application of noradrenaline with various pulse durations inhibited the spontaneous frequency of action potentials and hyperpolarized the membrane. Neuropeptide Y (NPY), its C-terminal fragment NPY(16–36) and peptide YY (PYY), at a concentration of 0.1 µmol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 µmol/l) was inactive. These results are compatible with the presence of Y2-type NPY-receptors at the cell somata of LC neurones.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00173217
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