Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Chronic anorexic and behavioural effects of the fenfluramine metabolite, norfenfluramine: An evaluation of its role in the actions of fenfluramine (1974)
    Springer
    Psychopharmacology 38 (1974), S. 67-74 
    Details
    ISSN: 1432-2072
    Keywords: Fenfluramine ; Norfenfluramine ; Anorexia ; Activity Analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The anorexic and behavioural effects of Norfenfluramine were studied in rats. Two separate experiments were conducted involving administration by intra-peritoneal and sub-cutaneous routes respectively. Behavioural effects were assessed by time sampling categorisation on Days 1 and 14 of a 20 day chronic study and anorexic effects by daily weighing. Norfenfluramine was found to be a potent anorexiant, to which tolerance is established fairly quickly. It was also found to possess sedative properties after acute administration, but marked stimulant properties after 14 days chronic administration. These results are similar to those previously reported in a study of Fenfluramine, although the behavioural effects of Norfenfluramine are more marked. The results implicate Norfenfluramine in the anorexic and behavioural effects of Fenfluramine, and provide indirect confirmation of the suggestion made in an earlier paper that Fenfluramine may have chronic stimulant properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421288
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Discriminative stimulus properties of fenfluramine in an operant task: An analysis of its cue function (1977)
    Springer
    Psychopharmacology 53 (1977), S. 97-102 
    Details
    ISSN: 1432-2072
    Keywords: Fenfluramine ; Norfenfluramine ; Amphetamine ; Drug discrimination ; Stimulus properties of drugs ; Fixed ratio responding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fenfluramine at a dose of 3.0 mg/kg was found to possess discriminative stimulus properties controlling lever selection by rats in a two-lever operant task. Subjects trained to discriminate the ‘Fenfluramine cue’ failed to generalize to amphetamine in extinction tests at doses between 0.25 and 1.0 mg/kg. Subjects did, however, generalize to the fenfluramine metabolite, norfenfluramine, at a dose of 2.0 mg/kg. These data provide further evidence for a pharmacological difference between fenfluramine and amphetamine, and support the hypothesis that norfenfluramine is an active metabolite of fenfluramine. The relevance of these findings to theoretical and methodological aspects of drug discrimination studies is considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426700
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...