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  • Nuclear Bodies  (2)
  • Atheromatous Material  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Subacute sclerosing panencephalitis (SSPE) reappraisal of nuclear, cytoplasmic and axonal inclusions ultrastructural study of eight cases (1974)
    Springer
    Acta neuropathologica 28 (1974), S. 1-13 
    Details
    ISSN: 1432-0533
    Keywords: Subacute Sclerosing Panencephalitis ; Intranuclear Inclusions ; Intracytoplasmic ; Intraaxonal Inclusions ; Nuclear Bodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A description of “nuclear bodies”, “intranuclear crystalloid tubules” and intracytoplasmic inclusions from eight SSPE cases in clinical stage 2 and 3 is presented. The development and evolution of nuclear bodies is proposed. No correlation between the clinical stage of the disease and the different morphological aspects of nuclear bodies was found. The presence of nuclear bodies in SSPE is a consistent feature and consequently these “structures” should have a definite diagnostic value in clinically suspected cases of SSPE. All the cases showed various types of intranuclear inclusions ranging from “simple” nuclear bodies to granular “beaded” nuclear bodies and paramyxovirus nucleocapsids. Intralysosomal nucleocapsids were found in one case. In one instance intraaxonal paramyxovirus nucleocapsids were found. Intranuclear elongated tubules and/or filamentous paracrystalline bundles, some arranged in lattice-like fashion were also found. No apparent morphological relationship was demonstrated between these structures and the “simple” nuclear bodies, granular “beaded” nuclear bodies and “nucleocapsids.” From these observations, we propose that “simple” nuclear bodies evolve into paramyxovirus nucleocapsids tubules and that there is a migration of virus or virus-related structures from nuclei to cytoplasm and then to axoplasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687513
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Progressive multifocal leukoencephalopathy with paramyxovirus-like structures, Hirano bodies and neurofibrillary tangles (1974)
    Springer
    Acta neuropathologica 27 (1974), S. 277-288 
    Details
    ISSN: 1432-0533
    Keywords: Progressive Multifocal Leukoencephalopathy ; Hirano Bodies ; Papova Virus ; Paramyxovirus-like ; Nuclear Bodies ; Electron Microscopy ; Neurofibrillary Tangles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have identified three structures that have not previously been reported in electron microscopic examinations of brain from patients with PML: 1. coiled nuclear bodies that may possibly represent tubular paramyxovirus nucleocapsids, 2. Hirano bodies and 3. Neurofibrillary tangles. The paramyxovirus-like material is interesting in view of reports of a transition between nuclear bodies and tubular paramyxovirus nucleocapsids and because of a possible interaction between syncytiogenic paramyxoviruses and Papova viruses in the pathogenesis of SSPE and PML. A study of the Hirano bodies in this case, taken in conjunction with the findings of others leads us to believe that these structures are formed from an overgrowth of neurofilaments. The presence of tangled masses of neurofilaments in the processes of neurons also seen in the present case is consistent with this hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690693
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Aseptic meningitis due to atheromatous material in the subarachnoid space (1974)
    Springer
    Acta neuropathologica 30 (1974), S. 145-154 
    Details
    ISSN: 1432-0533
    Keywords: Aseptic Meningitis ; Atheromatous Material ; Hypersensitivity ; Electron Microscopy ; Macrophages ; Pia-Arachnoid ; Granuloma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 500 mg of sterile pooled human atheromatous material was injected into the cisterna magna of 6 mongrel dogs. Repeated cisternal punctures were done at various intervals until sacrifice from 1 day to 28 days following injection. CSF was obtained for cell count, sugar, protein and analysis in the Technicon 6/60 which measured 14 additional chemical and enzymatic variables. All 6 animals showed a prompt cerebrospinal fluid (CSF) pleocytosis which largely subsided during the first 2 weeks after injection. Increased CSF protein content developed more slowly, but was more prolonged than the pleocytosis. There was a variable decrease in CSF sugar and increase in CSF lactate dehydrogenase, calcium and inorganic phosphorous. Light and electron microscopic studies showed an intense acute inflammatory reaction with marked phagocytosis of the foregin material, probably by arachnoidal cells and moderate edematous changes in the astrocytic processes at the site of injection. During the first 2 weeks after the injection the inflammatory reaction became chronic and the edematous changes in the medulla subsided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685439
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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