ZIB

Treffer pro Seite

Treffer 1 - 3 | 3 Treffer

Sortierung

Digitale Medien

Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors (1994)

Seaquist, E. R. ; Pyzdrowski, K. ; Moran, A. ; [weitere]

Springer

Diabetologia 37 (1994), S. 1036-1043

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-0428

Schlagwort(e): Key words Insulin action ; pancreatectomy ; glucose uptake ; pancreas transplantation ; minimal model.

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Healthy humans undergoing hemipancreatectomy for the purpose of donation to a family member with IDDM have previously been demonstrated to maintain serum glucose values equal to matched control subjects during short-term glucose infusion despite significant decrements in glucose- and arginine-induced insulin secretion. In order to determine whether humans compensate for hemipancreatectomy by increasing insulin- or glucose-mediated glucose uptake, we measured glucose turnover and insulin sensitivity by three protocols. Insulin-mediated glucose uptake was measured during sequential infusions of insulin at rates of 0.25, 1.0, and 10.0 mU · kg−1· min−1 in 12 donor subjects and 12 matched control subjects maintained at euglycaemia. Both groups displayed similar increases in rates of glucose disappearance and similar decreases in rates of hepatic glucose production. Glucose-mediated uptake was calculated as the difference between the rates of glucose disappearance measured during a hyperglycaemic clamp and a euglycaemic clamp performed at identical rates of insulin infusion and was also found to be similar in both donor subjects and control subjects. Both groups also had indistinguishable measures of insulin sensitivity and glucose effectiveness as determined by the minimal model technique. Therefore, donor subjects appear to compensate for diminished insulin secretion following hemipancreatectomy by an unidentified mechanism since neither insulin- nor glucose-mediated glucose uptake are increased. [Diabetologia (1994) 37: 1036–1043]

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00400467

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors (1994)

Seaquist, E. R. ; Pyzdrowski, K. ; Moran, A. ; [weitere]

Springer

Diabetologia 37 (1994), S. 1036-1043

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-0428

Schlagwort(e): Insulin action ; pancreatectomy ; glucose uptake ; pancreas transplantation ; minimal model

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Healthy humans undergoing hemipancreatectomy for the purpose of donation to a family member with IDDM have previously been demonstrated to maintain serum glucose values equal to matched control subjects during short-term glucose infusion despite significant decrements in glucose- and arginine-induced insulin secretion. In order to determine whether humans compensate for hemipancreatectomy by increasing insulin- or glucose-mediated glucose uptake, we measured glucose turnover and insulin sensitivity by three protocols. Insulin-mediated glucose uptake was measured during sequential infusions of insulin at rates of 0.25, 1.0, and 10.0 mU·kg−1·min−1 in 12 donor subjects and 12 matched control subjects maintained at euglycaemia. Both groups displayed similar increases in rates of glucose disappearance and similar decreases in rates of hepatic glucose production. Glucose-mediated uptake was calculated as the difference between the rates of glucose disappearance measured during a hyperglycaemic clamp and a euglycaemic clamp performed at identical rates of insulin infusion and was also found to be similar in both donor subjects and control subjects. Both groups also had indistinguishable measures of insulin sensitivity and glucose effectiveness as determined by the minimal model technique. Therefore, donor subjects appear to compensate for diminished insulin secretion following hemipancreatectomy by an unidentified mechanism since neither insulin- nor glucose-mediated glucose uptake are increased.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00400467

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

Ischaemic oculomotor nerve palsy (1985)

Teuscher, A. U. ; Meienberg, O.

Springer

Journal of neurology 232 (1985), S. 144-149

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-1459

Schlagwort(e): Oculomotor nerve palsy, ischaemic ; Pupil sparing ; Vascular risk factors ; Diabetes mellitus

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Of 61 patients with isolated third nerve palsy, 23 (38%) had the characteristic clinical features of an ischaemic oculomotor nerve palsy. The essential sign of this usually painful disorder of acute onset was a marked discrepancy between complete or severe paresis of the extraocular muscles innervated by the third nerve, and sparing of the pupillary sphincter. All patients had completely recovered within 3 months. Fourteen had a history or on follow-up had other cranial mononeuropathies. Except for two patients, all were above the age of 60 years. Of the 23 cases, 11 had diabetes mellitus and 8 an abnormal glucose tolerance test, while in 4 the latter was normal. Almost all had hypertension and were overweight, and half were smokers. In 18 patients, four or five vascular risk factors were present.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00313889

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Treffer 1 - 3 | 3 Treffer