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  • Antitumoral activities  (1)
  • Intestinal biopsy  (1)
  • Oncogene  (1)
  • 1
    ISSN: 1432-1084
    Schlagwort(e): Radiation dose ; Paediatric radiology ; X-ray equipment ; Intestinal biopsy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In paediatric radiology intestinal biopsies for the diagnosis of coeliac disease are performed using fluoroscopy. The radiation exposure to the child depends on the X-ray equipment. We report patient measurements from three different equipments (A, B and C) together with a phantom study simulating children of different thickness relative to age. The median values of the mean absorbed dose to the child in the irradiated volume were 1.2 mGy (A), 0.79 mGy (B) and 0.15 mGy (C). The results show that the increase in tube potential with increasing distance in one equipment decreases the dosage, and also that modern equipment should be employed. Particularly old image intensifiers should not be used. With an optimal choice of equipment the dosage to the child can be reduced fourfold. The combination of an optimal technique of sedation and an experienced operator can reduce the dosage tenfold.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. S23 
    ISSN: 1432-1335
    Schlagwort(e): 7-Hydroxycoumarin ; Antitumoral activities ; Oncogene ; Transformation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract 7-Hydroxycoumarin (7-HC) is a naturally occuring substance with a variety of biological activities, e.g. antitumoral and immunomodulatory action. the potential mechanisms of 7-HC action on tumor cells have been investigated in a model of mouse fibroblasts transformed by distinet retroviral vectors carrying the oncogenesmyc andras. Treatment of the different oncogenic transformants with 7-HC in non-cytotoxic concentrations causes a strong inhibition of their proliferative capacity as measured by growth curves. Furthermore, incubation of theras andmyc transformants with 7-HC abrogated soft agar colony formation when compared to untreated cultures. These changes in cell growth characteristics of the various oncogene-transformed mouse fibroblasts were transient, since removal of 7-HC from the cultures caused a reappearance of the transformed properties of these cells within 6 days. The 7-HC-mediated inhibition of the proliferative capacity of the transformants was preceded by a selective down-regulation of oncogene expression. These data suggest that 7-HC causes a reversible inhibition ofras- andmyc-induced neoplastic properties in transformed fibroblasts by selective down-regulation of retroviral RNA levels.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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