ISSN:
1434-0879
Keywords:
Prostate carcinoma
;
Prostatic neoplasms
;
Gene amplifications
;
Oncogenes
;
Advanced-stage disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Gene amplification is a model of proto-oncogene alterations occasionally observed in human tumors. This amplification can, in some cases, have prognostic value (N-myc in neuroblastoma, c-erbB2 and int-2 in breast cancer, etc.). Amplifications of the proto-oncogenes c-myc, c-erbB2 and int-2 have not yet been report in prostate adenocarcinoma, which, like breast cancer, is hormone dependent. We sought amplifications of these three proto-oncogenes by means of Southern blotting in 15 human prostate adenocarcinoma specimens, most of which were advanced (7 stage C and 6 stage D1 or D2). We confirmed the lack of c-myc and c-erbB2 amplification, regardless of the stage, in contrast to the case of breast cancer. Int-2 amplification was observed in one advanced tumor with bone metastases, out of a total of six stage D tumors. The precise frequency of int-2 amplification and its role in prostate carcinogenesis remain to be determined.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00296872
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