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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 73 (2000), S. 570-574 
    ISSN: 1432-1246
    Keywords: Key words Toluene diisocyanate ; Sampling efficiency ; Closed-face cassette ; Open-face cassette
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: A modified closed-face cassette was developed for sampling and derivatizing airborne toluene diisocyanate (TDI). Methods: The cassette was assembled as a regular two-piece cassette sampler except that the whole inner surface of the sampler was loaded with coated filters to ensure that all of the aspirated TDI react with 1-(2-pyridyl) piperazine (1-2pp). Results: A test atmosphere study showed that the sampling efficiencies were 89.4% and 94.3% for 2,4-TDI and 2,6-TDI. One-third of the 2,4-TDI and 2,6-TDI mass was constantly collected on the top and middle-rim filters. A polyurethane (PU)-manufacturing plant study revealed an average of 35% and 33% of both isomer masses collected on the top and middle-rim filters. The 2,4-TDI collection of the closed-face cassette sampling was 21% higher than that of open-face sampling. Furthermore, consistent isomeric compositions of airborne 2,4-/2,6- TDI obtained from both types of samplers validated the use of the modified cassette sampler. Conclusions: The closed-face cassette sampler is capable of a higher collection of airborne TDI and the technique involved is as simple and feasible as that of the open-face sampler.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-7780
    Keywords: Key words Meropenem ; β-Lactams ; Clinical isolated strains ; MIC (E-test)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 1999, a surveillance study was initiated in a hospital in Beijing to monitor the potency and spectrum of five extended-spectrum β-lactam antimicrobial agents (meropenem, imipenem, cefepime, ceftazidime, and cefoperazone/sulbactam) tested against 554 strains of bacteria. Five groups of organisms were tested by the E-test method, with results validated by concurrent quality control strain analysis. Results were tabulated, and 100% of quality assurance tests (16/16 tests) were within ranges recommended by the National Committee for Clinical Laboratory Standards. Of the five β-lactam drugs tested, meropenem and imipenem were the most active against all isolates tested. Overall, the rank order of activity of the five agents was: meropenem (94.6% susceptible) 〉 imipenem (90.1%) 〉 cefepime (77.6%), cefoperazone/sulbactam (77.5%), ceftazidime (76.6%). Ninety-five percent of Enterobacter were to meropenem, while 82% were susceptible to imipenem. Meropenem was more active than imipenem against Pseudomonas aeruginosa. The minimum inhibitory concentration (MIC) of meropenem was eightfold lower than that of imipenem. Meropenem had excellent activity against Haemophilus influenzae, Streptococcus pneumoniae, and oxacillin-susceptible staphylococci.
    Type of Medium: Electronic Resource
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