ISSN:
0570-0833
Keywords:
Chirality functions
;
Optical activity
;
Methane derivatives
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The optical activity can provide detailed information about the configuration and conformation of methane derivatives if the chirality function is resolved, according to the theory of chirality functions[3] and the quantum mechanical theory of the optical activity of methane derivatives[4], into its components which are compared with experimental data. A first step in this direction is undertaken in the present article and it will be shown that the second approximation method for determining the conformationally independent contribution to the optical activity yields quantitatively good results. Description of the overall optical rotation by this component is expectedly poor where interactions between ligands, e. g. hydrogen bonding, tend to favor specific conformations. A quantitative understanding of such additional effects appears promising in conjunction with analyses of the kind described.
Additional Material:
6 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.197300301
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