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Digitale Medien

Experimental studies on mutagenic and carcinogenic effects of tobacco chewing (1985)

Shah, A. S. ; Sarode, A. V. ; Bhide, S. V.

Springer

Journal of cancer research and clinical oncology 109 (1985), S. 203-207

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Details

ISSN: 1432-1335

Schlagwort(e): Chewing tobacco ; Nitrosamine ; Oral cancer

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The alcoholic extract of the chewing (Pandharpuri) variety of tobacco (Nicotiana tabaccum) was subjected to mutagenicity and tumorigenicity studies. The extract was found to be mutagenic in strain TA 98 of Salmonella typhimurium in the presence of S 9 mixture. It also induced 8 AZG-resistant mutation in V 79 Chinese hamster cells. Administration of tobacco extract to male Swiss mice by gavage or mixed with diet resulted in an increased incidence of lung/liver tumors. Further, an additive effect of tobacco extract and hexachlorocyclohexane on liver tumor induction was observed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00390358

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