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  • 1
    Digitale Medien
    Digitale Medien
    The association between blood lactate concentration on admission, duration of cardiac arrest, and functional neurological recovery in patients resuscitated from ventricular fibrillation (1997)
    Springer
    Intensive care medicine 23 (1997), S. 1138-1143 
    Details
    ISSN: 1432-1238
    Schlagwort(e): Key words Cardiac arrest ; Cardiopulmonary resuscitation ; Outcome ; Lactate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective: To assess the association between arterial lactate concentration on admission and the duration of human ventricular fibrillation cardiac arrest, and to what degree the arterial lactate concentration on admission is an early predictor of functional neurological recovery in human cardiac arrest survivors. Design: Cohort study. Arterial lactate concentrations and out-of-hospital data concerning cardiac arrest and cardiopulmonary resuscitation were collected retrospectively according to a standardized protocol. Functional neurological recovery was assessed prospectively at regular intervals for 6 months. Setting: Emergency department of an urban tertiary care hospital. Patients: A total of 167 primary survivors of witnessed out-of-hospital ventricular fibrillation cardiac arrest. Measurements: The association between arterial lactate concentration on admission, the duration of cardiac arrest, and functional neurological recovery was assessed. Further, we assessed whether admission concentrations of arterial lactate and duration of cardiac arrest can predict unfavorable functional neurological recovery. Functional neurological recovery was measured in cerebral performance categories (CPC). No or minimal functional impairment (CPC 1 and 2) was defined as favorable outcome; the remaining categories (CPC 3, 4 and 5) were defined as unfavorable functional neurological recovery. Results: In 167 patients, a weak association between total duration of cardiac arrest and admission levels of lactate (r = 0.49, P 〈 0.001) could be shown. With increasing admission concentrations of arterial lactate functional neurological recovery was more likely to be unfavorable (OR 1.15 per mmol/l increase, 95 % CI 1.04–1.27). Nevertheless, only at very high levels of lactate (16.3 mmol/l) could unfavorable neurological recovery be detected with 100 % specificity, yielding a very low sensitivity of 16 %. Conclusions: The arterial admission lactate concentration after out-of-hospital ventricular fibrillation cardiac arrest is a weak measure of the duration of ischemia. High admission lactate levels are associated with severe neurological impairment. However, this parameter has poor prognostic value for individual estimation of the severity of subsequent functional neurological impairment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001340050470
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  • 2
    Digitale Medien
    Digitale Medien
    Zur Stereochemie der Epoxycardanolide (IsogenineMit Ausnahme der Trivialnamen Digitoxigenin, Digoxigenin und Gitoxigenin halten wir uns streng an die «IUPAC-IUB 1967 Revised Tentative Rules for Steroid Nomenclature», Steroids 13, 277 ff. (1969).) (1972)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 55 (1972), S. 1352-1371 
    Details
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The stereochemistry of the epoxycardanolides 8, 21, 24 and 33, derived from digitoxigenin (1), digoxigenin (15), 3β, 14, 15β-trihydroxy-5β, 14β-card-20(22)-enolide (23) and gitoxigenin (27) respectively, is discussed on the basis of NMR. data. In the case of 1 and 15 the absolute configuration of the chiral centres C(20) and C(21) is assigned. Treatment of the cardenolides with KOH in methanol gave on dilution with methanol and subsequent acidification a number of acetal derivatives, the properties of which are described.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hlca.19720550503
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  • 3
    Digitale Medien
    Digitale Medien
    Zur Biogenese des Antibioticums Phomin. 1. Teil: Die Grundbausteine (1970)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 53 (1970), S. 1797-1812 
    Details
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A number of potential 14C- and 3H-labelled precursors were fed to growing cultures of Phoma spec. (Strain S 298), after the rate of formation of phomine (cytochalasin B; C29H37NO5) had been determined. By chemical degradation of [14C]-phomine and [3H, 14C]-phomine the distribution of the radioactivity originating from the incorporated precursors was determined. The results demonstrate that the building blocks of phomine are 1 unit of phenylalanine, 9 units of acetate or malonate respectively, and 2 units of methionine. Acetate acts as a starter and malonate as a propagator of a C16- or C18-chain. A possible combination of these elements leading to phomine and to 5-dehydrophomine is suggested.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hlca.19700530728
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  • 4
    Digitale Medien
    Digitale Medien
    Umsetzung von 3-O-Acetyl-14-anhydrodigitoxigenin und 3-O-Acetyldigitoxigenin mit Osmiumtetroxid (1971)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 54 (1971), S. 2007-2016 
    Details
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Treatment of 3-O-acetyl-14-anhydrodigitoxigenin (1) with 1.1 equivalents of OsO4 gave both the 14α, 15α-diol 2 and the 14β, 15β-diol 4. Degradation to the corresponding methyl etianates 7 and 10, respectively, established their stereochemistry. Treatment of both the 14-hydroxy-15-acetoxy-cardenolides 3 and 5 with OsO4 leads to the expected mixtures of 20, 22-diols, a partial separation of which was achieved after acetylation. The butenolide ring of 3-O-acetyl-digitoxigenin (25) also reacted with OsO4, yielding the two 20,22diols 26 and 27, the stereochemistry of which has tentatively been assigned on the basis of NMR. data.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hlca.19710540730
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  • 5
    Digitale Medien
    Digitale Medien
    Methylierungs-Reaktionen an 30-Oxa-[14]cytochalasanenWir verwenden die von Binder, Tamm et al. vorgeschlagenen halbsystematischen Namen anstelle der bisher benutzten Trivialnamen «Phomine» bzw. «Cytochalasine». Vgl. [1]. (1972)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 55 (1972), S. 2486-2494 
    Details
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: For synthetic studies the protection of the hydroxyl groups of phomin (cytochalasin B) ((7S,22R,26R)-7,26-dihydroxy-22-methyl-30-oxa-[14]cytochalasa-6(18), 19t 27t-trien-1,29-dion) (1), the dodecahydro-derivative 2, and the dihydro-derivative 4 by methylation was investigated. Treatment of 1 with CH3I/Ag2O gave the iminoether 6. The reaction of 4 with CH2N2/BF3 led to the di-O-methyl derivative 8 and to the N-methyl-di-O-methyl derivative 9, whereas 2 was transformed to the N-methyl-di-O-methyl compound 10 and to the iminoether 11.NaBH4 reduction of 3 yielded not only 4 but also the epimeric dihydro derivative 5.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hlca.19720550725
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