ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Condensation reactions of the 5-amino-6-(subst. amino)-2,4-dithiouracils 12 and 13 with diacetyl or benzil led to the 6,7,8-trisubstituted 2,4-dithiolumazines 14-16. Methylation of these compounds affected both thio functions forming various types of 2,4-bis(methylthio)lumazine derivatives depending on the nature of the substituents at C(7) and N(8). The 6,7,8-trimethyl-2,4-dithiolumazine (14) was converted into 7,8-dihydro-6,8-dimethyl-7-methylidene-2,4-bis(methylthio)pteridine (17), whereas the 8-methyl-6,7-diphenyl-(15) and the 8-(2-hydroxyethyl)-6,7-diphenyl-2,4-dithiolumazine (16) yielded the corresponding covalent inter- or intramolecular 7,8-adducts 18-21. The unusual structures were proven by spectroscopic means and those of the alcohol adducts 20 and 21, furthermore, confirmed by X-ray analysis.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19890720415
Permalink
