ISSN:
0894-3230
Keywords:
Organic Chemistry
;
Physical Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
A novel host is described which contains three potential binding sites, viz. a cleft and two crown ether rings. The molecule can adopt three different conformations. One of these is able to form a complex with two alkali metal ions. The binding of potassium ions is shown to be a cooperative process. The association constant of the second ion is 128 times larger than that of the first. The compound also binds 1,3-dinitrobenzene at the third site by π-π interactions. The complex with two potassium ions binds 1,3-dinitrobezene more strongly than does the free compound by a factor of 2-6, depending on the solvent used. This allosteric effect is caused by the conformational change which is induced by the binding of the potassium ions.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/poc.610051006
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