ISSN:
0268-2605
Keywords:
Titanium(IV) complexes
;
antitumour agents
;
ligand substitution
;
kinetics
;
mechanism
;
activation volume
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Rate laws and kinetic parameters are reported for substitution at titanium(IV) complexes Ti(LL)2X2, where LLH=cyclopentadiene, the 4-pyrone ethylmaltol, several 4-pyridinones, and related ligands, and X=halide or alkoxide, in acetonitrile solution at 298.2 K. Reactivities are discussed in terms of the nature of the leaving group, the entering group and the non-leaving ligand LL-. Activation volumes of -15 and -12 cm3 mol-1 have been determined for thiocyanate attack at Ti(cp)2Cl2 and Ti(etmalt)2Cl2 respectively. Substitution mechanisms are discussed in the light of the kinetic parameters obtained.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aoc.590070508
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