ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis of new photolabeling analogues of luteinizing hormone releasing hormone is described. Peptides were prepared by the solid-phase method, and the photolabeling moiety was introduced as the 4′-nitrophenyl-alanine precursor. This amino acid, either of the L or D configuration, was placed at different positions and was modified afterwards to 4′-azidophenylalanine. Structures with agonistic or antagonistic character were prepared, together with a peptide containing simultaneously the photolabeling moiety and a biotin substituent for future receptor isolations. Binding studies on placental and pituitary membranes indicate that these compounds represent promising candidates for receptor labeling studies.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19870700221
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