ISSN:
1434-4726
Keywords:
Cochlear blood flow
;
Hypoxia
;
Ototoxicity Laser Doppler flowmetry
;
Ginkgo biloba extract
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Ginkgo biloba extract (EGb 761) was administered orally for 4 or 6 weeks to healthy adult guinea pigs. Animals were then decapitated under deep ketamine anesthesia. Post-mortem morphometric measurements of cochlear vessels in the spiral lamina revealed a vasodilating effect of the extract in four of ten animals following 6 weeks of treatment. In vivo testing of the effect of 4 or 6 weeks of treatment with EGb 761 was monitored with laser Doppler flowmetry of the cochlear blood flow under pathological conditions. Results demonstrated that EGb 761 partly counteracted sodium salicylate-induced decreases in cochlear blood flow (CBF) and enhanced CBF increases induced by hypoxia. These findings indicate that EGb 761 may help to improve oxygenation in cochleas with compromised blood flow.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00176698
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