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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 56 (1978), S. 369-370 
    ISSN: 1432-1440
    Keywords: Inhibin ; Ovarian follicular fluid ; FSH-regulation ; Ovarian cycle ; Premenopause ; Ovar-Inhibin ; Follikelflüssigkeit ; FSH-Regulation ; Ovarieller Zyklus ; Prämenopause
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Aus Follikelflüssigkeit menschlicher Ovarien wurde durch Alkohol-Präzipitation ein steroidhormon-freier Proteinextrakt gewonnen. Dieser Rohextrakt hatte Inhibinwirkung und hemmte die Ovargewichtszunahme HCG behandelter infantiler Ratten und unterdrückte den nach Kastration infantiler männlicher Ratten auftretenden FSH-Anstieg im Serum. Rohextrakt aus Follikelflüssigkeit kleiner Follikel von Frauen mit regulären Zyklen enthielt pro mg Protein mehr Inhibin-Aktivität als Rohextrakt aus der Follikelflüssigkeit eines cystischen Follikels einer 53jährigen Frau in der Prämenopause. Die mögliche Bedeutung von Inhibin bei der Regulation des ovariellen Zyklus wurde diskutiert.
    Notes: Summary A steroid-free proteinaceous substance with inhibin-like activity has been extracted from human ovarian follicular fluid by alcohol precipitation. This substance was capable of inhibiting the ovarian weight increase of hCG-treated immature female rats and also of suppressing the post-castration rise of serum FSH levels in immature male rats. Follicular fluid from small follicls obtained from regularly cycling women was — on the basis of protein- found to be more active than cystic follicular fluid obtained from a premenopausal woman. The possible role of inhibin in the regulation of human ovarian cycle has been discussed.
    Type of Medium: Electronic Resource
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