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Studies on low-level MDR cells (1993)

Belvedere, G. ; Dolfini, E.

Springer

Cytotechnology 12 (1993), S. 257-264

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ISSN: 1573-0778

Keywords: low resistance ; MDR ; P-glycoprotein

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology

Notes: Abstract Acquired or spontaneous resistance is a major clinical problem in the treatment of cancer. Low levels of MDR gene expression or P-glycoprotein have been correlated with a high level of drug resistance in vitro and a poor response to chemotherapy in some tumors. A strong correlation between MDR mRNA, P-glycoprotein levels and degree of drug resistance has not been found in several resistant model tumor cell lines. In some cell lines at low and high level of resistance different mechanisms seem to be involved.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00744667

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