ISSN:
1420-908X
Keywords:
Paw oedema
;
PAF
;
Phlogogen agents
;
EFAD rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Carrageenin oedema is enhanced by the simultaneous injection in the rat paw of platelet activating factor (PAF). The enhancement of carrageenin oedema is observed throughout the time course of the experiments. This enhancement is also present when the oedema-producing agent is dextran, cellulose sulphate, histamine, 5-hydroxytryptamine, bradykinin or prostaglandin E2. Both verapamil and BN 52021 abolished the enhancement induced by PAF without modifying significantly carrageenin oedema. In essential fatty acid deficient (EFAD) rats depleted of kininogen and amines, carrageenin oedema is not modified by PAF. These findings suggest that PAF interacts with other inflammatory mediators regulating the formation of oedema induced by irritants injected locally.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02001907
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