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Digitale Medien

Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder (1988)

Kahn, Rene S. ; Asnis, Gregory M. ; Wetzler, Scott ; [weitere]

Springer

Psychopharmacology 96 (1988), S. 360-364

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Details

ISSN: 1432-2072

Schlagwort(e): Serotonin ; Receptor hypersensitivity ; Anxiety ; Cortisol ; Panic disorder ; MCPP

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Normal controls (NC) (n=15), patients with panic disorder (PD) (n=13) and patients with major depression (MD) (n=17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine (MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00216062

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