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  • 1
    Electronic Resource
    Electronic Resource
    Fate of photosensitizing furanocoumarins in tolerant and sensitive insects (1984)
    Springer
    Journal of chemical ecology 10 (1984), S. 893-911 
    Details
    ISSN: 1573-1561
    Keywords: Xanthotoxin ; psoralen ; isopsoralen ; furanocoumarin ; Papilio polyxenes ; Lepidoptera ; Papilionidae ; Spodoptera frugiperda ; Noctuidae ; metabolism ; detoxification ; tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The fate of [14C]xanthotoxin (8-methoxypsoralen) was studied in larvae of insect species that are tolerant (Papilio polyxenes Stoll) or sensitive (Spodoptera frugiperda J.E. Smith) to the phototoxic effects of photosensitizing psoralens. Both insects metabolize xanthotoxin by oxidative cleavage of the furan ring, but the detoxification occurs at a much more rapid rate inP. polyxenes in which 〉95% of an oral 5 μg/g xanthotoxin dose is metabolized within 1.5 hr after treatment. The detoxification of psoralens byP. polyxenes appears to occur primarily in the midgut tissue prior to absorption, with the result that the intact phototoxin does not reach appreciable levels in body tissues. Studies with an angular furanocoumarin indicated that isopsoralens are metabolized byP. polyxenes at a somewhat slower rate than observed for psoralens; however, a reduced rate of metabolic detoxification of isopsoralens probably does not explain the fact that psoralen tolerance inP. polyxenes does not extend to the isopsoralen series.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00987971
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative metabolism of [3H]psoralen and [3H]isopsoralen by black swallowtail (Papilio polyxenes Fabr.) caterpillars (1986)
    Springer
    Journal of chemical ecology 12 (1986), S. 871-884 
    Details
    ISSN: 1573-1561
    Keywords: Psoralen ; isopsoralen ; furanocoumarin ; Papilio polyxenes ; Lepidoptera ; Papilionidae ; metabolism ; detoxification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The comparative fate of tritiated preparations of a linear furanocoumarin (psoralen) and an angular furanocoumarin (isopsoralen) was determined in last-instar caterpillars of the black swallowtail butterfly (Papilio polyxenes Fabr.). Oral administration of either furanocoumarin at 5 μg/g is followed by rapid metabolism, primarily through oxidative cleavage of the furan ring, and the metabolites are rapidly excreted. Isopsoralen is, however, metabolized at a somewhat slower rate than is psoralen, and levels of unmetabolized isopsoralen in body tissues of the treated caterpillars are about three-fold higher. These data are compatible with the hypothesis that a reduced detoxification rate accounts at least in part for the susceptibility ofP. polyxenes caterpillars to the deleterious effect of isopsoralens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01020257
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    In vitro metabolism of a linear furanocoumarin (8-methoxypsoralen, xanthotoxin) by mixed-function oxidases of larvae of black swallowtail butterfly and fall armyworm (1986)
    Springer
    Journal of chemical ecology 12 (1986), S. 885-892 
    Details
    ISSN: 1573-1561
    Keywords: Aldrin ; xanthotoxin ; mixed-function oxidases ; black swallowtail butterfly ; fall armyworm ; Papilio polyxenes ; Spodoptera frugiperda ; Lepidoptera ; Papilionidae ; Noctuidae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Studies were made of the comparative in vitro metabolism of [14C]xanthotoxin and [14C]aldrin by homogenate preparations of midguts and bodies (carcass minus digestive tract and head) of last-stage larvae of the black swallowtail butterfly (Papilio polyxenes Fabr.) and the fall armyworm [Spodoptera frugiperda (J. E. Smith)]. The two substrates were metabolized by 10,000g supernatant microsomal preparations from both species. Evidence gained through the use of a specific inhibitor and cofactor indicated that mixed-function microsomal oxidases were major factors in the metabolism and that the specific activity of this enzyme system was considerably higher in midgut preparations fromP. polyxenes than in similar preparations fromS. frugiperda. Aldrin was metabolized 3–4 times faster byP. polyxenes, and xanthotoxin 6–6.5 times faster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01020258
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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