ISSN:
1432-1912
Keywords:
MIF
;
Melanostatin
;
Oxotremorine
;
Parkinson
;
Peptides
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Pro-Leu-Gly-NH2 (MIF) inhibits the tremor induced by oxotremorine. Objective measurement of this tremor permits the drawing of a dose-effect curve. The inhibitory effect of the peptide increases linearly with increasing doses until an optimum is reached (between 30 and 40 mg/kg i.p.). At still higher doses the peptide is inactive. The same phenomenon is observed with analogues of MIF. This finding may have important bearings on the interpretation of clinical and experimental data obtained with MIF.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00508614
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