ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Circular dichroism detection
;
Multiscan detection
;
Peak purity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A method has been developed to detect inhomogeneity of apparently homogeneous peaks of very similar analytes. The method utilizes the rapid scan feature of state-of-the-art spectrometers/detectors that allow the recording of up to 30 spectra in a single chromatographic peak. Sensitivity and selectivity are enhanced by chiroptical/optical detection. Thus, identification of “front” and “rear” components of the peak can be carried out. The method is exemplified by mixtures of codeine, hydrocodone and oxycodone as analytes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02466654
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