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  • 1
    Electronic Resource
    Electronic Resource
    Characterization of glycoconjugate expression during development of Meckel's cartilage in the rat (1995)
    Springer
    Anatomy and embryology 191 (1995), S. 47-59 
    Details
    ISSN: 1432-0568
    Keywords: Bone ; Lectins ; Mandible ; Meckel's cartilage ; Rat embryo
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The staining patterns of 24 biotinylated lectins were analyzed in serial sections of the mandible of 13- to 21-day-old rat embryos by means of the avidinbiotin-peroxidase method. A ubiquitous distribution of binding sites was demonstrated after incubation with Con A (Canavalia ensiformis), DSL (Datura stramonium; except bone matrix), and WGA (Triticum vulgare). ECL (Erythrina cristagalli), GSL I (Griffonia simplicifolia), SJA (Saphora japonica), VVL (Vicia villosa), DBA (Dolichus biflorus), UEA I (Ulex europeus), and LTA (Lotus tetragonobolus) were constantly negative. In early stages of development, GSL II (Griffonia simplicifolia II) was a selective marker of prechondral blastema. In contrast, PNA (Arachis hypogaea) did not stain condensing mesenchyme. During chondrogenesis of Meckels's cartilage a general decrease of lectin binding was observed. Mature cartilage matrix was constantly negative. Chondrocytes were marked by the lectins PSA (Pisum sativum), WGA, PHA-E, and PHA-L (Phaseolus vulgaris E and L). A strong GSL II binding was restricted to the mesial-superior region of the perichondrium. In later stages, several lectins revealed significant differences between preskeletal (“central”) areas and the remaining (“peripheral”) mesenchyme. A clear binding reaction was noted in central regions by applying LEA (Lycopersicon esculentum) and STL (Solanum tuberosum), while the peripheral tissue was only faintly stained. Developing bone was specifically marked by succinylated WGA (sWGA). The lectins LCA (Lens culinarus) and RCA (Ricinus communis) bound to fibers and extracellular matrix of the connective tissue. Jacalin (Artocarpus integrifolia) and SBA (Glycine max) binding sites were found in macrophages. Affinity of VAA (Viscum album) increased parallel with maturation of endothelial cells. Specific lectin-binding patterns revealed no correlation with the distribution of glycosaminoglycans. The results demonstrate a general reduction of oligosaccharide structures during development of Meckel's cartilage. From our observations we conclude that intralaminar glucose and/or mannose sequences as well as terminal sialic acid molecules are ubiquitously distributed, while terminal α-fucose was constantly negative. Lectin-binding patterns of macrophages may reflect the presence of specifically linked terminal galactose. Our findings indicate that oligosaccharides terminating in N-acetylglucosamine are bone-specific. The significance of the restricted staining of the perichondrium by GSL II remains to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215297
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  • 2
    Electronic Resource
    Electronic Resource
    Therapieergebnisse peptischer Oesophagusstenosen (1980)
    Springer
    Langenbeck's archives of surgery 353 (1980), S. 155-170 
    Details
    ISSN: 1435-2451
    Keywords: Peptic stenosis ; Barrett's syndrome ; Endobrachyesophagus ; Fundoplication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 118 peptischen Stenosen, die zwischen 1970 und 1979 zur Behandlung kamen, waren 89 (75,4%) im Zusammenhang mit einem Endobrachyoesophagus, d. h. im Verlauf einer primären Refluxkrankheit, entstanden, 26 als Folge einer sekundären Refluxkrankheit ohne Endobrachyoesophagus. In drei Fällen mußte die peptische Stenose als Resultat einer lokalen Säureproduktion gedeutet werden. Die Therapie erfolgte konservativ (Bougierung und Cimetidin/Antacida) oder operativ (Bougierung und Fundoplicatio). Die Therapieergebnisse waren je nach Stenosetyp unterschiedlich. Bei hochsitzenden Stenosen (mit Endobrachyoesophagus) waren gute Ergebnisse unter konservativer Therapie in 39,3%, unter operativer Therapie in 67,3% der Fälle erreichbar. Die Ergebnisse bei den terminalen Stenosen waren vergleichbar (konservative Therapie 45,5%, operative Therapie 60%). Die retrospektive Analyse der Therapieversager zeigt, daß vorwiegend narbige Stenosen schlechtere Ergebnisse zeigen als floride Stenosen mit frischer Oesophagitis.
    Notes: Summary Of 118 patients treated for peptic stenosis between 1970 and 1979, 89 cases (75.4%) had developed in connection endobrachyesophagus, i. e., as the result of primary reflux disease; 26 cases were the consequence of secondary reflux disease without endobrachyesophagus. In three cases the peptic stenosis had to be explained as the result of a local acid secretion. The treatment which followed was conservative (bougienage + Cimetidine/Antacids) or operative (bougienage + fundoplication). The results of the therapy varied according to the type of stenosis. In cases where the stenosis was located in the upper part (endobrachyesophagus), good results could be achieved with conservative therapy in 38.3% and with operative therapy, in 67.3%. The results were worse in terminal stenosis (conservative therapy, 45.5%; operative therapy, 60%). Retrospective analysis of unsuccesful treatment shows that predominantly scarred stenosis shows worse results than florid stenosis with recent esophagitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01261960
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    283. Chirurgie peptischer Oesophagusstenosen (1980)
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 600-600 
    Details
    ISSN: 1435-2451
    Keywords: Peptic stenosis ; Barrett syndrome columnar cell lined lower oesophagus ; Fundoplication ; Peptische Oesophagusstenose ; Barrett-Syndrom ; Endobrachyoesophagus ; Fundoplicatio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 118 peptischen Stenosen, die zwischen 1970 und 1979 zur Behandlung kamen, waren 89 (75,4 %) im Zusammenhang mit einem Endobrachyoesophagus, d. h. im Verlauf einer primären Refluxkrankheit, entstanden; 26 als Folge einer sekundären Refluxkrankheit ohne Endobrachyoesophagus. In drei Fällen mußte die peptische Stenose als Resultat einer lokalen Säureproduktion gedeutet werden. Die Therapie erfolgte konservativ (Bougierung + Cimetidin/Antacida) oder operativ (Bougierung + Fundoplicatio). Die Therapieergebnisse waren je nach Stenosetyp unterschiedlich. Bei hochsitzenden Stenosen (mit Endobrachyoesophagus) waren gute Ergebnisse unter konservativer Therapie in 39,3%, unter operativer Therapie in 67,3 % der Fälle erreichbar. Die Ergebnisse bei den terminalen Stenosen waren schlechter (konservative Therapie 45,5%, operative Therapie 60,0%), Die retrospektive Analyse der Therapieversager zeigt, daÜ vorwiegend narbige Stenosen schlechtere Ergebnisse zeigen als floride Stenosen mit frischer Oesophagitis.
    Notes: Summary Out of 118 peptic stenoses treated between 1970 and 1979, 89 (75.4 %) had developed in connection with a lower columnar cell lined oesophagus, i. e. as the result of a primary reflux disease; 26 as the consequence of a secondary reflux disease without columnar cell lined lower oesophagus. In three cases the peptic stenosis had to be explained as the result of a local acid secretion. The treatment which followed was conservative (bouginage + cimetidine/antacids) or operative (bouginage + fundoplication). The results of the therapy varied according to the stenosis type. In cases of high located stenoses (with columnar cell lined lower oesophagus) good results could be achieved under conservative therapy in 38.3 %, under operative therapy in 67.3 % of cases. The results amongst the terminal stenoses were worse (conservative therapy 45.5%, operative therapy 60.0%). The retrospective analysis of the unsuccessful treatment shows that predominantly scarred stenoses show worse results than florid stenoses with fresh oesophagitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292248
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    Paper (German National Licenses)
    Fulltext
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