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  • 1
    Electronic Resource
    Electronic Resource
    Localized hypertrophic neuropathy: possible focal perineurial barrier defect (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 514-518 
    Details
    ISSN: 1432-0533
    Keywords: Hypertrophic mononeuropathy ; Localized hypertrophic neuropathy ; Perineurium ; Compartmentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Localized hypertrophic neuropathy (hypertrophic mononeuropathy) is a rare benign condition that generally occurs in people under 40 years of age. Our immunocytochemical (S-100 protein) study of four new cases confirms previous observations that the cells forming the hypertrophic onion bulb are composed of perineurial cells. These observations and previously published illustrations, reveal a curious hyalinization of the outer perineurium of affected fascicles which suggests the absence of a perineurial barrier. Compartmentation (compartmentalization) of the endoneurium in hypertrophic mononeuropathy closely mimics the transient compartmentation which occurs in the distal nerve stumps of axotomized nerves, particularly in nerves in which re-innervation is prevented. Compartmentalization also can be produced by resection of the perineurial sheath. These findings suggest that hypertrophic mononeuropathy may be a reactive condition due to focal damage to the perineurial barrier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687253
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pregression of perineurial cell basement membrane in a human diabetic following isogenic pancreas transplant (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 108-112 
    Details
    ISSN: 1432-0533
    Keywords: Diabetes mellitus ; Diabetic neuropathy ; Pancreas transplantation ; Perineurium ; Perineurial cell basement membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Perineurial cell basement membrane (PCBM) thickening is a consistent feature in diabetes mellitus (DM) and may have relevance to the cause of DM neuropathy. In this ultrastructural morphometric study of identical twins discordant for DM, we found that the PCBM was significantly thicker in the dermal nerves of the diabetic twin. Following pancreas transplantation (PT) and a 2-year period of euglycemia, the PCBM in both dermal and sural nerves was significantly thinner. At the end of the 2nd year post-PT, the PCBM thickness in the dermal nerves of the diabetic was not significantly different from the non-DM twin. The correction of diabetic dysmetabolism may have played a role in the regression of PCBM. These data suggest that PCBM thickening may not be a permanent legacy of DM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308966
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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