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Phase I trial of 4′-deoxydoxorubicin given weekly (1984)

Sessa, C. ; Bosia, L. ; Kaplan, S. ; [et al.]

Springer

Investigational new drugs 2 (1984), S. 369-374

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ISSN: 1573-0646

Keywords: Phase I trial ; 4′-deoxydoxorubicin ; esorubicin

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Twenty-six patients with various solid tumors entered a Phase I trial with 4′ -Deoxydoxorubicin (Esorubicin, IMI-58), a new doxorubicin analogue. The drug was administered weekly i.v. for 3–4 weeks. Leukopenia proved to be dose limiting. The maximum tolerated dose (MTD) was reached at 20 mg/m2 weekly for 3 weeks. For Phase II trials, a weekly dose of 15 and 17.5 mg/m2 can be proposed for poor and good risk patients respectively. Non-hematologic toxicity was minimal. Phase II trials with this new anthracycline are warranted.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00171587

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