ISSN:
1432-0584
Keywords:
Photochemical virus inactivation
;
Phenothiazine dyes
;
Human fresh plasma
;
Neoantigens
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Photodynamic virus inactivation of human fresh plasma mediated by visible light in the presence of the phenothiazine dyes methylene blue or toluidine blue was investigated to determine whether it influences functional, structural, and immunological properties of plasma proteins. The activities of the coagulation factors I, VIII, IX, X, and XI were affected to a certain degree, while those of most other plasma proteins were not. The elution profiles obtained by ion exchange chromatography of untreated and photodynamically treated plasma were almost identical. Using a number of antisera against human plasma and single plasma proteins, different immunochemical techniques revealed identical patterns for untreated and treated plasma. Thus, there was no indication that the photodynamic virus inactivation procedure applied considerably influences the properties of plasma proteins.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01703949
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