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  • Chemical Engineering  (22)
  • Analytical Chemistry and Spectroscopy  (21)
  • Physical Chemistry  (4)
  • 1
    Digitale Medien
    Digitale Medien
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 14 (1987), S. 603-607 
    ISSN: 0887-6134
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Fractional dietary Ca absorption, ‘a’, is measured by determining the ratio of two stable isotopic tracers, one of them orally (44Ca @ 0.2-0.5 mg/kg) and the other intravenously (42Ca @ 0.02-0.1 mg/kg). Thermal ionization mass spectrometry (TIMS) is used to measure the perturbation of natural abundance isotope ratios (delta % excess). Typical sensitivity of the TIMS permits detection of a 2.5 delta % excess change from the natural Ca isotope ratio with relative standard deviations of about 0.5%. At sufficiently long times absorption becomes constant so that ‘a’ is determined by a product of constants and a measured ratio.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 41 (1995), S. 415-425 
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: A 1-D model, which neglects radial variations, describes the hydrodynamics of cell-free ultrafiltration hollow-fiber bioreactors (HFBRs) and the transport of highmolecular-weight proteins trapped in the extracapillary space (ECS). The profiles of radially-averaged protein concentrations predicted by this model are identical to those obtained using a model with radial variations. The model predictions agree well with axial profiles of bovine serum albumin (BSA) and human transferrin concentrations measured in transient and steady-state experiments. The validated model explores the influence of cell culture operating conditions on HFBR protein transport. Increasing protein loading decreases BSA and transferrin polarization in HFBRs operated with unidirectional lumen flow. A relationship developed predicts the protein loading needed to ensure a nonzero steady-state protein concentration throughout the ECS. This critical protein loading depends only on the lumen pressure drop and the ECS protein osmotic pressure. Periodic reversal of the lumen flow direction also decreases protein polarization. The influence of the flow-direction switching time and membrane permeability on the ECS protein distribution is investigated.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 39 (1993), S. 904-907 
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 41 (1995), S. 805-811 
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: A mathematical model of mass transport through dispersed-phase networks to be used for the sustained release of drugs or other solutes at steady rates is presented. The drug is assumed to be encapsulated within the dispersed microdomains and transported to the bulk by diffusion across the interface. A drug is released to the surroundings by diffusion through the bulk. The results show that the desired steady flux of a drug to the surroundings may be obtained given appropriate values of structural properties of the network. These properties may be manipulated easily in the fabrication of dispersed-phase networks reported previously.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 8 (1962), S. 266-271 
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Turbulent flow friction factors were determined for flocculated suspensions of thoria, kaolin, and titania in tubes 1/8- to 1-in. diameter. The non-Newtonian laminar flow data were arbitrarily fitted with the Bingham plastic model. With this model the range of yield stress values was 0.018 to 1.39 lb.f/sq. ft., with a maximum ratio of coefficient of rigidity to viscosity of suspending medium of 11.1. The volume fraction solids were varied from 0.042 to 0.23.Two types of behavior were observed depending on the value of the yield stress. For yield values less than 0.5 lb.f/sq. ft. the turbulent friction factors were always less than those for Newtonian fluids but tended to approach the Newtonian values as the Reynolds number was increased. For yield values greater than 0.5 lb.f/sq. ft. the friction factors were again less than those for New-tonian fluids but tended to diverge from the Newtonian values as the Reynolds number was increased. Both sets of data were correlated with the Blasius relation with the coefficient and exponent given in terms of the laminar flow properties und the volume fraction solids.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 8 (1962), S. 373-378 
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The minimum transport velocity (defined as the mean-stream velocity required to prevent the accumulation of a layer of stationary or sliding particles on the bottom of a horizontal conduit) vas determined in a 1-in. pipe for an aqueous suspension of glass beads using glass beads having mean diameters of 78 and 310 μ.The results of the present study were combined with prior pneumatic- and hydraulic-transport data for air and water suspensions to give a unique minimum-transport relation, valid for particles larger than the thickness of the laminar sublayer, that is for particles which are immersed in the buffer layer or which extend into the turbulent core when resting on the pipe wall. The correlation showed that the ratio of particle settling velocity to friction velocity at the minimum transport condition was a function of particle Reynolds number, pipe Reynolds number, and the relative density ratio of particle to fluid. The results of the correlation suggest that a single mechanism is responsible for the initiation of particle transport throughout the range of conditions covered. This mechanism may be identified with Bernoulli forces due to instantaneous velocity differences accompanying turbulent fluctuations and largely confined to the buffer layer.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 10 (1964), S. 517-523 
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: In the absence of turbulent fluctuations the main effect of a velocity gradient on the floc properties is a rearrangement of particles within the floc producing a more dense floc structure. When the suspension is sufficiently dilute that floc-floc collisions are negligible, the limits on the floc diameter are (1 + α)5/3 〈 (Df/Dp) ≤ (1 + α)2, where α is the ratio of the volume of fluid immobilized in the floc structure to volume of solids in the floc structure as determined from hindred-settling measurements. These results set an upper limit on the floc size.Under turbulent flow conditions the principle mechanism leading to floc rupture is pressure differences on opposite sides of the floc which cause bulgy deformation and rupture. The breakup of the floc is resisted by the yield stress τy and is promoted by an increase in the energy dissipation per unit mass of fluid ∊. Because the energy dissipation per unit mass is at a maximum near the pipe wall, the floc size is at a minimum in this same region.By application of the concepts of local isotropy, the floc size is found to be proportional to (τy9/∊5)1/2once the turbulent intensity is sufficient to overcome the yield stress. In the wall region the floc diameter is proportional to (du/dr)3 (τy9/∊8)1/2.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 10 (1964), S. 303-308 
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Four different flow regimes may be identified during transport of dilute suspensions of solid particles through horizontal pipes by liquids in turbulent flow as the velocity is varied. The regimes may be characterized by the distribution of solids in the channel. In two of the regimes the bulk of the material is immediately adjacent to the bottom of the channel and is clumped up either into transverse waves (dunes or islands) with a reproducible periodicity or into longitudinal waves (long stria). The definition of the other two regimes is somewhat more arbitrary but may qualitatively be described as heterogeneous or homogeneous flow. Extensive studies of the conditions under which transverse and longitudinal waves occurred, when combined with results of previous studies, showed that all four of these flow regimes may be conveniently represented on a single diagram in which the terminal-settling velocity divided by the friction velocity and the Reynolds number on particle diameter and friction velocity are the coordinates. Because the particle Reynolds number based on the terminal-settling velocity can be uniquely defined as an additional parametre on such a diagram the particular flow behavior for any given combination of system and particle characteristics can be readily determined.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 11 (1965), S. 520-525 
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The effect of free stream turbulence level on forced convection through laminar and turbulent boundary layers on a flat was studied in a wind tunnel with a small but nonzero favorable pressure gradient by means of the naphthalene sublimation technique.With the small favorable pressure gradient used in this study, the rate of forced convection through laminar boundary layers agreed with Polhausen's theoretical equation for turbulence levels less than 2.8% but increased in a regular fashion for turbulence levels greater than 2.8% and was almost tripled at a free stream turbulence level of 11%. There was no evidence of an interaction between pressure gradient and turbulence level which would produce disproportionate effects on the rate of forced convection through laminar boundary layers. Substantially no effect of turbulence level on forced convection through turbulent boundary layers was observed for turbulence levels up to 7%.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 12 (1966), S. 124-130 
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Enhanced rates of mass transfer in the wake region behind detached cylindrical turbulence promoters were investigated with the use of the naphthalene sublimation technique. The maximum increase in the average rate of mass transfer through laminar boundary layers was over 170%. The remarkable feature of these results was that the enhanced rates of mass trasfer persisted for over one hundred and thirty cylinder diameters downstream from the cylinder generating the wake. The observed effect was not only strongly dependent on the free stream velocity and the location of the cylinders relative to the mass transfer surface, but there were marked differences observed between the rate of mass transfer in the wake region behind one and behind two cylinders. These results resemble a “tuning phenomenon” and are believed to be due to Tollmein-Schlichting instabilities and premature transition.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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