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  • 1
    Electronic Resource
    Electronic Resource
    Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 59-66 
    Details
    ISSN: 1435-1463
    Keywords: Cytotoxicity ; isoquinolines ; N-methylsalsolinol ; 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion ; neuroblastoma SH-SY5Y cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Endogenous isoquinolines with and without catechol structure have been proposed to be neurotoxins specific for dopamine neurons. In this paper they were examined for the cytotoxicity of human dopaminergic neuroblastoma SH-SY5Y cells. The cytotoxicity was quantitatively determined using Alamar Blue assay, by which the reduction-oxidation potency in the living cells can be measured spectrometrically. 1,2-Dimethyl-6,7-dihydroxyisoquinolinium ion [1,2-DMDHIQ+], an oxidation product of a parkinsonism-inducing isoquinoline, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahyroisoquinoline [N-methyl-(R)salsolinol, NM(R)Sal] was found to be the most potent toxin among isoquinolines examined. In general, catechol isoquinolines were more toxic than isoquinolines without catechol structure. With and without catechol structure, the oxidized isoquinolinium ion having methyl groups at C-1 and N-2 positions proved to be more cytotoxic than the simple isoquinolines. The involvement of 1,2-DMDHIQ+ to the neurotoxicity of NM(R)Sal was suggested and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271294
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  • 2
    Electronic Resource
    Electronic Resource
    Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system (1994)
    Springer
    Journal of neural transmission 98 (1994), S. 107-118 
    Details
    ISSN: 1435-1463
    Keywords: Uptake ; inhibition ; dopamine transporter ; 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline ; 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline ; 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion ; neuroblastoma SH-SY5Y cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Uptake of catechol isoquinolines to dopamine cells was studied using human dopaminergic neuroblastoma SH-SY5Y cells. Only (R)-1,2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [(R)-1,2-DiMeDHTIQ] was transported by dopamine uptake system, while (S)-1,2-DiMeDHTIQ, (R)- and (S)-1-methyl-6,7-dihydroxy-tetrahydroisoquinoline, and 1,2-dimethyl-6,7-dihydroxyisoquinolinum ion were not. Kinetical study showed that the uptake of (R)-1,2-DiMeDHTIQ followed the Michaelis-Menten equation, and the values of the Michaelis constant and the maximal velocity were obtained to be 102.6 ± 36.9 μM and 66.0 ± 2.8 pmol/min/mg protein. Dopamine was found to inhibit (R-1-DiMeDHTIQ uptake competitively. These results suggest that the selective uptake by dopamine transporter may account for the specific neurotoxicity of (R)-1,2-DiMeDHTIQ to dopamine neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277014
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  • 3
    Electronic Resource
    Electronic Resource
    Morphological studies of liquid-crystalline cellulose derivatives. II. Hydroxypropyl cellulose films prepared from liquid-crystalline aqueous solutions (1985)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 23 (1985), S. 1053-1064 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A morphological study of hydroxypropyl cellulose (HPC) was performed on solid films prepared by casting from a liquid-crystalline aqueous solution at rest or under shear. Electron microscopic observations reveal that many round particles composed of stacked disks are densely packed in the interior of a quiescently cast HPC film, while on the film surface formation of fibrous textures is also noted. Shear-deformed HPC films exhibit some interesting morphological features according to the shearing conditions. It is found by electron microscopy that the originally round particles become more and more elongated as shear stress increases. The resulting rodlike fibrillar entities are considerably aligned in the shear direction (SD), but form a banded structure with periodic discontinuities of molecular orientation distribution along the SD. A new mechanism of structural transformation is proposed in order to interpret these results.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1985.180230515
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  • 4
    Electronic Resource
    Electronic Resource
    Morphological studies of liquid-crystalline cellulose derivatives. I. Liquid-crystalline characteristics of hydroxypropyl cellulose in 2-hydroxyethyl methacrylate solutions and in polymer composites prepared by bulk polymerization (1985)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 23 (1985), S. 1043-1052 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The formation of liquid-crystalline structure in hydroxypropyl cellulose (HPC) in the solvent 2-hydroxyethyl methacrylate (HEMA) is described. In addition, an attempt is made to preserve the ordered structure of HPC in a composite by polymerizing the solvent. Optical evidence, including refractive index, absorption spectra, polarized-light microscopy, and x-ray diffraction, indicates that HPC-HEMA solutions exhibit the cholesteric nature of the mesophase over limited concentration and temperature ranges. The polymer composite (HPC-PHEMA) prepared from the liquid-crystalline solution by polymerization of HEMA is endowed with anisotropic organization reflecting liquid-crystalline character. Detailed morphological observations of the composite by electron microscopy show many round particles composed of parallel-stacked, disklike lamellae, and aggregate bodies developed by coalescence of neighboring particles.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1985.180230514
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  • 5
    Electronic Resource
    Electronic Resource
    Kinetics of radiation-induced grafting reactions. I. Polyethylene-styrene systems (1972)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 10 (1972), S. 259-273 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: By means of bromine labeling and ESR, the grafting reactions of styrene onto preirradiated polyethylene have been investigated. Not all the radicals produced by irradiations participate in grafting reactions all together, but they are rendered active bit by bit by the swelling of crystalline parts of polyethylene. The growing rates for polystyryl graft chains at 20°C decrease from 4 monomer units/active site/sec to one-fourth the initial value after 100 min. On the contrary, the average lifetimes increase from 〈103 sec to 〉2.6 × 103 sec. The number-average molecular weight of graft chains also increases with reaction times and rises to 3.5 × 105 after 90 min at 20°C.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1972.150100123
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