ISSN:
1434-0879
Keywords:
Placental-like alkaline phosphatase
;
Testicular cancer
;
smokers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Serum PLAP/PLAP-like enzymes are elevated in testicular cancer patients and also in heavy smokers. Such elevations were measurable with anti-PLAP polyclonal and monoclonal antibodies, and an antigenic heterogeneity was demonstrated in the circulating enzymes. Thus polyclonal antibody revealed more of tumor PLAP-like antigen while a monoclonal antibody H7 detected PLAP of smokers better. PLAP of smokers and PLAP-like enzyme of cancer (seminoma) patients showed similar characteristics with respect to glycosylation pattern, charge and hydrophobicity. By these properties they were differentiated from PLAP of placenta.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00295842
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