ISSN:
1435-1463
Keywords:
Platelet
;
monoamine oxidase B
;
3 H-imipramine binding
;
Alzheimer's disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Several biochemical abnormalities in peripheral tissues have been reported in Alzheimer's disease (AD). With this in mind we studied platelet monoamine oxidase B (MAO B) activity and 3H-imipramine (IMI) binding in both AD patients and healthy subjects and found a significantly higher level of platelet MAO B activity and 3 H-IMI Bmax values in the AD patients. In view of the part that MAO B plays in metabolizing serotonin (5 HT) and of the relationship which exists between 3 H-IMI binding and 5 HT uptake, our results would suggest that with AD there occurs a complex dysfunction in the 5 HT system, at least at a peripheral level.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02260901
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