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The effects of protriptyline and clomipramine in vitro on the uptake of 5-hydroxytryptamine and dopamine in human platelet-rich plasma (1975)

Trenchard, Ann ; Turner, P. ; Pare, C. M. B. ; [et al.]

Springer

Psychopharmacology 43 (1975), S. 89-93

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ISSN: 1432-2072

Keywords: Uptake ; Platelets ; 5-Hydroxytryptamine ; Dopamine ; Inhibition ; Protriptyline ; Clomipramine

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The effects of protriptyline and clomipramine, at concentrations of 10−7 M to 10−4 M, were studied in vitro on the uptake of 5-hydroxytryptamine and dopamine uptake in human platelet-rich plasma. It was found that the tertiary amine, clomipramine, was a more potent inhibitor of 5-hydroxytryptamine uptake than the secondary amine, protriptyline. The activity of both compounds was competitive but it was thought unlikely that they acted through tryptamine receptor sites as methysergide 2.5×10−8 M had very little effect on 5-hydroxytryptamine uptake. Neither tricyclic antidepressant had any marked effect on dopamine uptake.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00437621

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A Rapid, Accurate Technique for Determining Densities of High Explosives (1977)

Lagus, P. L. ; Turner, P. L. ; Gaffney, E. S.

Weinheim : Wiley-Blackwell

Propellants, Explosives, Pyrotechnics 2 (1977), S. 81-84

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ISSN: 0721-3115

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Notes: An improved gas comparison pycnometer has been developed, based on precise differential pressure measurements coupled with a sample volume compensator. Using helium gas, volumes of solid and powdered explosives can be measured to a precision approaching one part in lo4. Coupled with a precise mass measurement, these volumes allow densities with an uncertainty of ∼± 0.002 g/ml to be inferred. Measurements performed on various explosives have allowed assessment of the purity and homogeneity of individual samples. It is also possible to infer void percentage or porosity in pressed explosive pellets.

Additional Material: 2 Ill.