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116. Experimentelle Untersuchungen über eine neuartige gesprühte Kunststoffprothese (1981)

Gruss, J. D. ; Braun, B. ; Lehnhardt, F. J. ; [et al.]

Springer

Langenbeck's archives of surgery 355 (1981), S. 517-517

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ISSN: 1435-2451

Keywords: Polyurethane graft ; Microporosity ; Control angiography ; Scanning electronic microscopy ; Polyurethanprothesen ; Mikroporosität ; Kontrollangiographie ; Rasterelektronenmikroskopie

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Description / Table of Contents: Zusammenfassung Die neuen Kunststoffprothesen bestehen aus Polyúrethan, das nach einem speziellen Sprühverfahren verarbeitet wird. Die Prothesen sind längs- und querelastisch sowie mikroporös. In tierexperimentellen Untersuchungen wurden 20mal die terminale Aorta, 24mal die arteria carotis communis und 12mal die arteria femoralis superficialis ersetzt. Die Tiere wurden in regelmäßigen Abst↭den angiographiert. Nach Tötung erfolgten rasterelektronenmikroskopische und histologische Untersuchungen. Von 20 Aortentransplantaten blieben 18 bis zum Zeitpunkt der Tötung, bzw. bis heute offen. In Carotisposition scheinen sich die Transplantate nicht zu bewähren.

Notes: Summary The new plastic graft consists of polyurethane manufactured in a special spray process. These grafts are elastic both transversally and longitudinally and are microporous. In experiments on animals, the abdominal aorta was substituted 20 times, the common carotid artery 24 times, and the superficial femoral artery 12 times. The animals were regularly subjected to angiographical examinations. After they were killed, they were examined histologically and by means of a scanning electronic microscope. Of the 20 abdominal grafts, 18 have remained open to date. Carotis grafts, however, seemed to fail.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01286945

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Significance of the inner-surface structure of small-caliber prosthetic blood vessels in relation to the development, presence, and fate of a neo-intima. A morphological evaluation (1984)

Hess, F. ; Jerusalem, C. ; Grande, P. ; [et al.]

Hoboken, NJ : Wiley-Blackwell

Journal of Biomedical Materials Research 18 (1984), S. 745-755

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ISSN: 0021-9304

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine , Technology

Notes: Microvascular prostheses with three different inner surface structures were examined morphologically 1-18 months after implantation to evaluate the presence and structure of the neo-intima. Fibrous polyurethane tubes (length: 5-10 mm, inner diameter: 1.5 mm) were implanted in the rat abdominal aorta in group A with a fibrillar inner structure (pore sizes 20-50 m̈m), and in group B the inner fibrillar structure was coated with an impermeable continuous silicon sheet. Expanded polytetrafluorethylene vascular prostheses (length: 40 mm, inner diameter: 4 mm) were implanted in the dog carotid artery (group C). The specimens were examined by light microscopy and scanning electron microscopy. A continuous and permanent neointima was only found in the prostheses with the porous fibrillar inner structure (group A). The thin new lining sheet was well attached to the prosthetic wall by cellular protrusions. In the silicon-coated prostheses (group B) also a continuous neo-intima had developed which, however, was irregular, thicker, and not anchored to the prosthetic wall. The expanded polytetrafluorethylene prostheses (group C) showed also after 1 year only incomplete lining with a neo-intima. Fresh blood cell deposits could be observed in the unlined prosthetic wall. It is concluded that a continuous lining of vascular grafts with a thin neo-intima is only achieved if the cells invading the prostheses from the anastomotic areas can anchore their cytoplasmic protrusions onto an appropriately structured inner surface. If these anchoring facilities are not provided, the unattached neo-intima will thicken, interfering with the patency of these microvascular prostheses, or fragments of the neo-intima or alternatively mural thrombi may constantly strip off and embolize.

Additional Material: 7 Ill.