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  • 1
    Electronic Resource
    Electronic Resource
    Treatment of AIDS-related non-Hodgkin's lymphoma with chemotherapy (CNOP) and r-hu-G-CSF: Clinical outcome and effect on HIV-1 viral load (1998)
    Springer
    Annals of oncology 9 (1998), S. 1135-1138 
    Details
    ISSN: 1569-8041
    Keywords: AIDS ; chemotherapy ; G-CSF ; HIV-1 viral replication ; non-Hodgkin's lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: The optimal treatment of AIDS-related NHL (ARL) has yet to be defined. The purpose of this study was 1) to evaluate the efficacy and toxicity of the CNOP-regimen (cyclophosphamide, mitoxantrone, vincristine, and prednison) in combination with G-CSF; and 2) to study the effect of this regimen on HIV-1 viral replication. Patients and methods: A phase II study was performed in 21 previously untreated patients with ARL. Results: Based on intention to treat, the response rate was 43%: four complete and five partial remissions. Median survival was only five months. Only one patient had an opportunistic infection during treatment; three patients had localized infections and one episode of septicaemia was seen. Remarkably, during treatment, in 94% of cases p24 antigen levels either remained undetectable or showed a substantial decrease, even though antiretroviral therapy had been discontinued just prior to the first cycle of chemotherapy in all patients. HIV-1 RNA load decreased or remained unchanged in 82% of patients and increased in three patients. Conclusions: Our data demonstrate, 1) that the CNOP-regimen in combination with G-CSF, although associated with a low risk of both opportunistic and bacterial infections, can not be recommended in the treatment of ARL; but 2) that G-CSF can be used safely to sustain haematopoiesis in patients with ARL treated with chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008484522952
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  • 2
    Electronic Resource
    Electronic Resource
    Permeationsuntersuchungen an stabilisierten Schaumlamellen (1979)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 30 (1979), S. 426-431 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The time-dependence of the permeation of methanol vapour through tenside-alginate foam lamels was determined by measuring the permeation, diffusion and solubility coefficients. Steady-state transport was found to occur only within narrow time limits. The agreement of calculated and experimental relationships between the coefficients suggest solution diffusion as proposed by BARRER. The transport mechanism can be explained by the place exchange theory and by the cluster theory according to LUCK.
    Notes: Für Tensid/Alginat-Schaumlamellen wurde der Durchtritt von Methanoldampf an Hand der Permeations-, Diffusions-und Löslichkeitskoeffizienten in Abhängigkeit von der Zeit ermittelt. Stationäre Transportzustände existieren nur in engen Zeitintervallen. Aus der Übereinstimmung zwischen den berechneten und experimentell ermittelten Koeffizienten-Beziehungen wird auf eine Lösungsdiffusion nach BARRER geschlossen. Der Transportmechanismus kann auf der Grundlage der Platzwechseltheorie sowie der Cluster-Theorie nach LUCK gedeutet wurden.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1979.010300710
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  • 3
    Electronic Resource
    Electronic Resource
    Dehydrocyclisierung von n-Hexan an bimetallischen Platin-Katalysatoren auf der Basis säurebehandelter Kieselgele (1978)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 50 (1978), S. 956-957 
    Details
    ISSN: 0009-286X
    Keywords: Heterogene Katalyse ; Platin-Trägerkatalysatoren ; Bimetall-Katalysatoren ; Dispersität ; Aromatisierung ; Hydrogenolyse ; Aromatisierung ; n-Hexan ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330501214
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